The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our primary analysis comprised a cross-trait analysis of the 1000 single-nucleotide polymorphisms (SNPs) with the lowest P-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence... Mehr ...
| Verfasser: |
Hinney, A
Kesselmeier, M
Jall, S
Volckmar, A-L
Föcker, M
Antel, J
Heid, I M
Winkler, T W
Grant, S F A
Guo, Y
Bergen, A W
Kaye, W
Berrettini, W
Hakonarson, H
Herpertz-Dahlmann, B
de Zwaan, M
Herzog, W
Ehrlich, S
Zipfel, S
Egberts, K M
Adan, R
Brandys, M
van Elburg, A
Boraska Perica, V
Franklin, C S
Tschöp, M H
Zeggini, E
Bulik, C M
Collier, D
Scherag, A
Müller, T D
Hebebrand, J
Hottenga, J.J.
Willemsen, Gonneke
Boomsma, D.I.
van Beijsterveldt, C.E.M.
Middeldorp, C.M.
de Geus, Eco |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2017 |
| Reihe/Periodikum: |
Hinney , A , Kesselmeier , M , Jall , S , Volckmar , A-L , Föcker , M , Antel , J , Heid , I M , Winkler , T W , Grant , S F A , Guo , Y , Bergen , A W , Kaye , W , Berrettini , W , Hakonarson , H , Herpertz-Dahlmann , B , de Zwaan , M , Herzog , W , Ehrlich , S , Zipfel , S , Egberts , K M , Adan , R , Brandys , M , van Elburg , A , Boraska Perica , V , Franklin , C S , Tschöp , M H , Zeggini , E , Bulik , C M , Collier , D , Scherag , A , Müller , T D , Hebebrand , J , GCAN , Hottenga , J J , Willemsen , G , Boomsma , D I , van Beijsterveldt , C E M , Middeldorp , C M & de Geus , E 2017 , ' Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index ' , Molecular Psychiatry , vol. 22 , no. 2 , pp. 192-201 . https://doi.org/10.1038/mp.2016.71 |
| Schlagwörter: |
Alleles
/ Anorexia Nervosa
/ Body Mass Index
/ Body Weight
/ Databases
/ Genetic
/ Female
/ Gene Frequency
/ Genetic Loci
/ Genetic Predisposition to Disease
/ Genetic Variation
/ Genome-Wide Association Study
/ Humans
/ Journal Article
/ Linkage Disequilibrium
/ Male
/ Obesity
/ Polymorphism
/ Single Nucleotide
/ Risk Factors
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29214548 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/afd14457-f8b3-48e9-b348-4d625fdf7166 |
