Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci
Endometriosis is a chronic inflammatory condition in women that results in pelvic pain and subfertility, and has been associated with decreased body mass index (BMI). Genetic variants contributing to the heritable component have started to emerge from genome-wide association studies (GWAS), although the majority remain unknown. Unexpectedly, we observed an intergenic locus on 7p15.2 that was genome-wide significantly associated with both endometriosis and fat distribution (waist-to-hip ratio adjusted for BMI; WHRadjBMI) in an independent meta-GWAS of European ancestry individuals. This led us... Mehr ...
| Verfasser: |
Rahmioglu, N.
Macgregor, S.
Drong, A.W.
Hedman, A.K.
Harris, H.R.
Randall, J.C.
Prokopenko, I.
Hottenga, J.J.
Boomsma, D.I.
Nyholt, DR
Morris, A.P.
Montgomery, G.W.
Missmer, S.A.
Lindgren, C.M.
Zondervan, K.T. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2015 |
| Reihe/Periodikum: |
Rahmioglu , N , Macgregor , S , Drong , A W , Hedman , A K , Harris , H R , Randall , J C , Prokopenko , I , Hottenga , J J , Boomsma , D I , Nyholt , DR , Morris , A P , Montgomery , G W , Missmer , S A , Lindgren , C M & Zondervan , K T 2015 , ' Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci ' , Human Molecular Genetics , vol. 24 , no. 4 , pp. 1185-1199 . https://doi.org/10.1093/hmg/ddu516 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29214494 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/a6e64216-33aa-4aef-a6ee-2a2cc06809fb |
