Novel genetic loci associated with hippocampal volume

Verfasser:	Hibar, Derrek P Adams, Hieab H H Jahanshad, Neda Chauhan, Ganesh Stein, Jason L Hofer, Edith Renteria, Miguel E Bis, Joshua C Arias-Vasquez, Alejandro Ikram, M Kamran Desrivières, Sylvane Vernooij, Meike W Abramovic, Lucija Alhusaini, Saud Amin, Najaf Andersson, Micael Arfanakis, Konstantinos Aribisala, Benjamin S Armstrong, Nicola J Athanasiu, Lavinia Axelsson, Tomas Beecham, Ashley H Beiser, Alexa Bernard, Manon Blanton, Susan H Bohlken, Marc M Boks, Marco P Bralten, Janita Brickman, Adam M Carmichael, Owen Chakravarty, M Mallar Chen, Qiang Ching, Christopher R K Chouraki, Vincent Cuellar-Partida, Gabriel Crivello, Fabrice Den Braber, Anouk Doan, Nhat Trung Ehrlich, Stefan Giddaluru, Sudheer Goldman, Aaron L Gottesman, Rebecca F Grimm, Oliver Griswold, Michael E Guadalupe, Tulio Gutman, Boris A Hass, Johanna Haukvik, Unn K Hoehn, David Holmes, Avram J Hoogman, Martine Janowitz, Deborah Jia, Tianye Jørgensen, Kjetil N Karbalai, Nazanin Kasperaviciute, Dalia Kim, Sungeun Klein, Marieke Kraemer, Bernd Lee, Phil H Liewald, David C M Lopez, Lorna M Luciano, Michelle Macare, Christine Marquand, Andre F Matarin, Mar Mather, Karen A Mattheisen, Manuel McKay, David R Milaneschi, Yuri Muñoz Maniega, Susana Nho, Kwangsik Nugent, Allison C Nyquist, Paul Loohuis, Loes M Olde Oosterlaan, Jaap Papmeyer, Martina Pirpamer, Lukas Pütz, Benno Ramasamy, Adaikalavan Richards, Jennifer S Risacher, Shannon L Roiz-Santiañez, Roberto Rommelse, Nanda Ropele, Stefan Rose, Emma J Royle, Natalie A Rundek, Tatjana Sämann, Philipp G Saremi, Arvin Satizabal, Claudia L Schmaal, Lianne Schork, Andrew J Shen, Li Shin, Jean Shumskaya, Elena Smith, Albert V Sprooten, Emma Strike, Lachlan T Teumer, Alexander Tordesillas-Gutierrez, Diana Toro, Roberto Trabzuni, Daniah Trompet, Stella Vaidya, Dhananjay Van Der Grond, Jeroen Van der Lee, Sven J Van der Meer, Dennis Van Donkelaar, Marjolein M J Van Eijk, Kristel R Van Erp, Theo G M Van Rooij, Daan Walton, Esther Westlye, Lars T Whelan, Christopher D Windham, Beverly G Winkler, Anderson M Wittfeld, Katharina Woldehawariat, Girma Wolf, Christiane Wolfers, Thomas Yanek, Lisa R Yang, Jingyun Zijdenbos, Alex Zwiers, Marcel P Agartz, Ingrid Almasy, Laura Ames, David Amouyel, Philippe Andreassen, Ole A Arepalli, Sampath Assareh, Amelia A Barral, Sandra Bastin, Mark E Becker, Diane M Becker, James T Bennett, David A Blangero, John van Bokhoven, Hans Boomsma, Dorret I Brodaty, Henry Brouwer, Rachel M Brunner, Han G Buckner, Randy L Buitelaar, Jan K Bulayeva, Kazima B Cahn, Wiepke Calhoun, Vince D Cannon, Dara M Cavalleri, Gianpiero L Cheng, Ching-Yu Cichon, Sven Cookson, Mark R Corvin, Aiden Crespo-Facorro, Benedicto Curran, Joanne E Czisch, Michael Dale, Anders M Davies, Gareth E De Craen, Anton J M De Geus, Eco J C De Jager, Philip L De Zubicaray, Greig I Deary, Ian J Debette, Stéphanie DeCarli, Charles Delanty, Norman Depondt, Chantal DeStefano, Anita Dillman, Allissa Djurovic, Srdjan Donohoe, Gary Drevets, Wayne C Duggirala, Ravi Dyer, Thomas D Enzinger, Christian Erk, Susanne Espeseth, Thomas Fedko, Iryna O Fernández, Guillén Ferrucci, Luigi Fisher, Simon E Fleischman, Debra A Ford, Ian Fornage, Myriam Foroud, Tatiana M Fox, Peter T Francks, Clyde Fukunaga, Masaki Gibbs, J Raphael Glahn, David C Gollub, Randy L Göring, Harald H H Green, Robert C Gruber, Oliver Gudnason, Vilmundur Guelfi, Sebastian Håberg, Asta K Hansell, Narelle K Hardy, John Hartman, Catharina A Hashimoto, Ryota Hegenscheid, Katrin Heinz, Andreas Le Hellard, Stephanie Hernandez, Dena G Heslenfeld, Dirk J Ho, Beng-Choon Hoekstra, Pieter J Hoffmann, Wolfgang Hofman, Albert Holsboer, Florian Homuth, Georg Hosten, Norbert Hottenga, Jouke-Jan Huentelman, Matthew Pol, Hilleke E Hulshoff Ikeda, Masashi Jack, Clifford R Jenkinson, Mark Johnson, Robert Jönsson, Erik G Jukema, J Wouter Kahn, René S Kanai, Ryota Kloszewska, Iwona Knopman, David S Kochunov, Peter Kwok, John B Lawrie, Stephen M Lemaître, Hervé Liu, Xinmin Longo, Dan L Lopez, Oscar L Lovestone, Simon Martinez, Oliver Martinot, Jean-Luc Mattay, Venkata S McDonald, Colm McIntosh, Andrew M McMahon, Francis J McMahon, Katie L Mecocci, Patrizia Melle, Ingrid Meyer-Lindenberg, Andreas Mohnke, Sebastian Montgomery, Grant W Morris, Derek W Mosley, Thomas H Mühleisen, Thomas W Müller-Myhsok, Bertram Nalls, Michael A Nauck, Matthias Nichols, Thomas E Niessen, Wiro J Nöthen, Markus M Nyberg, Lars Ohi, Kazutaka Olvera, Rene L Ophoff, Roel A Pandolfo, Massimo Paus, Tomas Pausova, Zdenka Penninx, Brenda W J H Pike, G Bruce Potkin, Steven G Psaty, Bruce M Reppermund, Simone Rietschel, Marcella Roffman, Joshua L Romanczuk-Seiferth, Nina Rotter, Jerome I Ryten, Mina Sacco, Ralph L Sachdev, Perminder S Saykin, Andrew J Schmidt, Reinhold E Schmidt, Helena Schofield, Peter R Sigursson, Sigurdur Simmons, Andrew Singleton, Andrew Sisodiya, Sanjay M Smith, Colin Smoller, Jordan W Soininen, Hilkka Steen, Vidar M Stott, David J Sussmann, Jessika E Thalamuthu, Anbupalam Toga, Arthur W Traynor, Bryan J Troncoso, Juan Tsolaki, Magda Tzourio, Christophe Uitterlinden, Andre G Hernández, Maria C Valdés Van der Brug, Marcel van der Lugt, Aad van der Wee, Nic J A Van Haren, Neeltje E M van 't Ent, Dennis Van Tol, Marie-Jose Vardarajan, Badri N Vellas, Bruno Veltman, Dick J Völzke, Henry Walter, Henrik Wardlaw, Joanna M Wassink, Thomas H Weale, Michael E Weinberger, Daniel R Weiner, Michael W Wen, Wei Westman, Eric White, Tonya Wong, Tien Y Wright, Clinton B Zielke, Ronald H Zonderman, Alan B Martin, Nicholas G van Duijn, Cornelia M Wright, Margaret J Longstreth, Jr. W.T. Schumann, Gunter Grabe, Hans J Franke, Barbara Launer, Lenore J Medland, Sarah E Seshadri, Sudha Thompson, Paul M Ikram, M Arfan
Dokumenttyp:	Artikel
Erscheinungsdatum:	2017
Reihe/Periodikum:	Hibar , D P , Adams , H H H , Jahanshad , N , Chauhan , G , Stein , J L , Hofer , E , Renteria , M E , Bis , J C , Arias-Vasquez , A , Ikram , M K , Desrivières , S , Vernooij , M W , Abramovic , L , Alhusaini , S , Amin , N , Andersson , M , Arfanakis , K , Aribisala , B S , Armstrong , N J , Athanasiu , L , Axelsson , T , Beecham , A H , Beiser , A , Bernard , M , Blanton , S H , Bohlken , M M , Boks , M P , Bralten , J , Brickman , A M , Carmichael , O , Chakravarty , M M , Chen , Q , Ching , C R K , Chouraki , V , Cuellar-Partida , G , Crivello , F , Den Braber , A , Doan , N T , Ehrlich , S , Giddaluru , S , Goldman , A L , Gottesman , R F , Grimm , O , Griswold , M E , Guadalupe , T , Gutman , B A , Hass , J , Haukvik , U K , Hoehn , D , Holmes , A J , Hoogman , M , Janowitz , D , Jia , T , Jørgensen , K N , Karbalai , N , Kasperaviciute , D , Kim , S , Klein , M , Kraemer , B , Lee , P H , Liewald , D C M , Lopez , L M , Luciano , M , Macare , C , Marquand , A F , Matarin , M , Mather , K A , Mattheisen , M , McKay , D R , Milaneschi , Y , Muñoz Maniega , S , Nho , K , Nugent , A C , Nyquist , P , Loohuis , L M O , Oosterlaan , J , Papmeyer , M , Pirpamer , L , Pütz , B , Ramasamy , A , Richards , J S , Risacher , S L , Roiz-Santiañez , R , Rommelse , N , Ropele , S , Rose , E J , Royle , N A , Rundek , T , Sämann , P G , Saremi , A , Satizabal , C L , Schmaal , L , Schork , A J , Shen , L , Shin , J , Shumskaya , E , Smith , A V , Sprooten , E , Strike , L T , Teumer , A , Tordesillas-Gutierrez , D , Toro , R , Trabzuni , D , Trompet , S , Vaidya , D , Van Der Grond , J , Van der Lee , S J , Van der Meer , D , Van Donkelaar , M M J , Van Eijk , K R , Van Erp , T G M , Van Rooij , D , Walton , E , Westlye , L T , Whelan , C D , Windham , B G , Winkler , A M , Wittfeld , K , Woldehawariat , G , Wolf , C , Wolfers , T , Yanek , L R , Yang , J , Zijdenbos , A , Zwiers , M P , Agartz , I , Almasy , L , Ames , D , Amouyel , P , Andreassen , O A , Arepalli , S , Assareh , A A , Barral , S , Bastin , M E , Becker , D M , Becker , J T , Bennett , D A , Blangero , J , van Bokhoven , H , Boomsma , D I , Brodaty , H , Brouwer , R M , Brunner , H G , Buckner , R L , Buitelaar , J K , Bulayeva , K B , Cahn , W , Calhoun , V D , Cannon , D M , Cavalleri , G L , Cheng , C-Y , Cichon , S , Cookson , M R , Corvin , A , Crespo-Facorro , B , Curran , J E , Czisch , M , Dale , A M , Davies , G E , De Craen , A J M , De Geus , E J C , De Jager , P L , De Zubicaray , G I , Deary , I J , Debette , S , DeCarli , C , Delanty , N , Depondt , C , DeStefano , A , Dillman , A , Djurovic , S , Donohoe , G , Drevets , W C , Duggirala , R , Dyer , T D , Enzinger , C , Erk , S , Espeseth , T , Fedko , I O , Fernández , G , Ferrucci , L , Fisher , S E , Fleischman , D A , Ford , I , Fornage , M , Foroud , T M , Fox , P T , Francks , C , Fukunaga , M , Gibbs , J R , Glahn , D C , Gollub , R L , Göring , H H H , Green , R C , Gruber , O , Gudnason , V , Guelfi , S , Håberg , A K , Hansell , N K , Hardy , J , Hartman , C A , Hashimoto , R , Hegenscheid , K , Heinz , A , Le Hellard , S , Hernandez , D G , Heslenfeld , D J , Ho , B-C , Hoekstra , P J , Hoffmann , W , Hofman , A , Holsboer , F , Homuth , G , Hosten , N , Hottenga , J-J , Huentelman , M , Pol , H E H , Ikeda , M , Jack , C R , Jenkinson , M , Johnson , R , Jönsson , E G , Jukema , J W , Kahn , R S , Kanai , R , Kloszewska , I , Knopman , D S , Kochunov , P , Kwok , J B , Lawrie , S M , Lemaître , H , Liu , X , Longo , D L , Lopez , O L , Lovestone , S , Martinez , O , Martinot , J-L , Mattay , V S , McDonald , C , McIntosh , A M , McMahon , F J , McMahon , K L , Mecocci , P , Melle , I , Meyer-Lindenberg , A , Mohnke , S , Montgomery , G W , Morris , D W , Mosley , T H , Mühleisen , T W , Müller-Myhsok , B , Nalls , M A , Nauck , M , Nichols , T E , Niessen , W J , Nöthen , M M , Nyberg , L , Ohi , K , Olvera , R L , Ophoff , R A , Pandolfo , M , Paus , T , Pausova , Z , Penninx , B W J H , Pike , G B , Potkin , S G , Psaty , B M , Reppermund , S , Rietschel , M , Roffman , J L , Romanczuk-Seiferth , N , Rotter , J I , Ryten , M , Sacco , R L , Sachdev , P S , Saykin , A J , Schmidt , R E , Schmidt , H , Schofield , P R , Sigursson , S , Simmons , A , Singleton , A , Sisodiya , S M , Smith , C , Smoller , J W , Soininen , H , Steen , V M , Stott , D J , Sussmann , J E , Thalamuthu , A , Toga , A W , Traynor , B J , Troncoso , J , Tsolaki , M , Tzourio , C , Uitterlinden , A G , Hernández , M C V , Van der Brug , M , van der Lugt , A , van der Wee , N J A , Van Haren , N E M , van 't Ent , D , Van Tol , M-J , Vardarajan , B N , Vellas , B , Veltman , D J , Völzke , H , Walter , H , Wardlaw , J M , Wassink , T H , Weale , M E , Weinberger , D R , Weiner , M W , Wen , W , Westman , E , White , T , Wong , T Y , Wright , C B , Zielke , R H , Zonderman , A B , Martin , N G , van Duijn , C M , Wright , M J , Longstreth , J W T , Schumann , G , Grabe , H J , Franke , B , Launer , L J , Medland , S E , Seshadri , S , Thompson , P M & Ikram , M A 2017 , ' Novel genetic loci associated with hippocampal volume ' , Nature Communications , vol. 8 , 13624 , pp. 13624 . https://doi.org/10.1038/ncomms13624
Schlagwörter:	Journal Article / /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR)
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-29214213
Datenquelle:	BASE; Originalkatalog
Powered By:	BASE
Link(s) :	https://research.vu.nl/en/publications/8dcfd9e4-0a05-4a12-8a72-1a68533da704

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.