OBJECTIVE - At least 20 type 2 diabetes loci have now been identified, and several of these are associated with altered β-cell function. In this study, we have investigated the combined effects of eight known β-cell loci on insulin secretion stimulated by three different secretagogues during hyperglycemic clamps. RESEARCH DESIGN AND METHODS - A total of 447 subjects originating from four independent studies in the Netherlands and Germany (256 with normal glucose tolerance [NGT]/ 191 with impaired glucose tolerance [IGT]) underwent a hyperglycemic clamp. A subset had an extended clamp with addi... Mehr ...
| Verfasser: |
Hart, L.M.
Bik-Simonis, A.M.C.
Nijpels, G.
van Haeften, T.W.
Schäfer, S.A.
Houwing-Duistermaat, J.J.
Boomsma, D.I.
Groenewoud, M.J.
Reiling, E.
van Hove, E.C.
Diamant, M.
Kramer, M.H.H.
Heine, R.J.
Maassen, J.A.
Kirchhoff, K.
Machicao, F.
Häring, H.U.
Slagboom, P.E.
Willemsen, G.
Eekhoff, E.M.W.
de Geus, E.J.C.
Dekker, J.J.M.
Fritsche, A. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2010 |
| Reihe/Periodikum: |
Hart , L M , Bik-Simonis , A M C , Nijpels , G , van Haeften , T W , Schäfer , S A , Houwing-Duistermaat , J J , Boomsma , D I , Groenewoud , M J , Reiling , E , van Hove , E C , Diamant , M , Kramer , M H H , Heine , R J , Maassen , J A , Kirchhoff , K , Machicao , F , Häring , H U , Slagboom , P E , Willemsen , G , Eekhoff , E M W , de Geus , E J C , Dekker , J J M & Fritsche , A 2010 , ' Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First Phase Glucose Stimulated Insulin Secretion During Hyperglycemic Clamps ' , Diabetes , vol. 59 , no. 1 , pp. 287-292 . https://doi.org/10.2337/db09-0736 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29214126 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/8296cfb4-d670-4ca8-a328-1dcdcd8b7fb3 |
