Directional dominance on stature and cognition in diverse human populations

Verfasser:	Joshi, P.K. Esko, T. Mattsson, H. Eklund, N. Gandin, I. Nutile, T. Jackson, A.U. Schurmann, C. Smith, A.V. Zhang, W. Okada, Y. Stancáková, A. Faul, J.D. Zhao, W. Bartz, T.M. Pina Concas, M. Franceschini, N. Enroth, S. Vitart, V. Trompet, S. Guo, X. Chasman, D.I. O'Connel, J.R. Corre, T. Nongmaithem, S.S. Chen, Y. Mangino, M. Ruggiero, D. Traglia, M. Farmaki, A.-E. Kacprowski, T. Bjonnes, A. Spek, A. Wu, Y. Giri, A.K. Yanek, L.R. Wang, L. Hofer, E. Rietveld, C.A. McLeod, O. Cornelis, M.C. Pattaro, C. Verweij, N. Baumbach, C. Abdellaoui, A. Warren, H.R. Vuckovic, D. Mei, H. Bouchard, C. Perry, J.R.B. Cappellani, S. Mirza, S.S. Benton, M.C Broeckel, U. Medland, S.E. Lind, P.A. Malerba, G. Drong, A. Yengo, L. Bielak, L.F. Zhi, D. van der Most, P.J. Shriner, D. Mägi, R. Hemani, G. Karaderi, T. Wang, Z. Liu, T. Demuth, I. Zhao, J.H. Meng, W. Lataniotis, L. van der Laan, S.W. Brafdfield, J.P. Wood, A.R. Bonnefond, A. Ahluwalia, T.S. Hall, L.M. Salvi, E. Yazar, S. Carstensen, L. de Haan, H.G. Abney, M. Afzal, U. Allison, M.A. Amin, N. Asselbergs, F.W. Bakker, S.J.L. Barr, R.G. Baumeister, S.E. Benjamin, D.J. Bergmann, S. Boerwinkle, E. Bottinger, E.P. Campbell, A. Chakravarti, A. Chan, Y. Chanock, S.J. Chen, C. Chen, Y.D.I. Colins, F.S. Connell, J. Correa, A. Cupples, L.A. Davey Smith, G. Davies, G. Dörr, M. Ehret, G. Ellis, S.B. Feenstra, B. Feitosa, M.F. Ford, I. Fox, C.S. Frayling, T.M. Friedrich, N. Geller, F. Gillham-Nasenya, I. Gottesman, O. Graff, M. Grodstein, F. Gu, C. Haley, C. Hammond, C.J. Harris, S.E. Harris, T.B. Hastie, N.D. Heard-Costa, N.L. Heikkilä, K. Hocking, L.J. Homuth, G. Hottenga, J.J. Huang, J. Huffman, J.E. Hysi, P.G. Arfan Ikram, M. Ingelsson, E. Joensuu, A. Johansson, A. Jousilahti, P. Jukema, J.W. Kähönen, M. Kamatani, Y. Kanoni, S. Kerr, S.M. Khan, N.M. Koellinger, P. Koistinen, H.A. Kooner, M.K. Kubo, M. Kuusisto, J. Lahti, J. Launer, L.J. Lea, R.A. Lehne, B. Lehtimäki, T. Liewald, D.C.M. Lind, L. Loh, M. Lokki, M.L. London, S.J. Loomis, S.J. Loukola, A. Lu, Y. Lumley, T. Lundqvist, A. Männistö, S. Marques-Vidal, P. Masciullo, C. Matchan, A. Mathias, R.A. Matsuda, K. Meigs, J.B. Meisinger, C. Meitinger, T. Menni, C. Mentch, F.D. Mihailov, E. Milani, L. Montasser, M.E. Montgomery, G.W. Morrison, A. Myers, R.H. Nadukuru, R. Navarro, P. Nelis, M. Nieminen, M.S. Nolte, I.M. O'Connor, G.T. Ogunniyi, A. Padmanabhan, S. Palmas, W.R. Pankow, J.S. Patarcic, I. Pavani, F. Peyser, P.A. Pietilainen, K.H. Poulter, N. Prokopenko, I. Ralhan, S. Redmond, P. Rich, S.S. Rissanen, H. Robino, A. Rose, L.M. Rose, R. Sala, C. Salako, B. Salomaa, V. Sarin, A.-P. Saxena, R. Schmidt, H. Scott, L.J. Scott, W.R. Sennblad, B. Seshadri, S. Sever, P. Shrestha, S. Smith, B.H. Smith, J.A. Soranzo, N. Sotoodehnia, N. Southam, L. Stanton, A.V. Stathopoulou, M.G. Strauch, K. Strawbridge, R.J. Suderman, M.J. Tandon, N. Tang, S.T. Taylor, K.D. Tayo, B.O. Töglhofer, A.M. Tomaszewski, M. Tsernikova, N. Tuomilehto, J. Uitterlinden, A.G. Vaidya, D. Hylckama Vlieg, A. van Setten, J. Vasankari, T. Vedantam, S. Vlachopoulou, E. Vozzi, D. Vuoksimaa, E. Waldenberger, M. Ware, E.B. Wentworth-Shields, W. Whitfield, J.B. Wild, S. Willemsen, G. Yajnik, C.S. Yao, J. Zaza, G. Zhu, X. Salem, R.M. Melbye, M. Bisgaard, H. Samani, N.J. Cusi, D. Mackey, D.A. Cooper, R.S. Froguel, P. Pasterkamp, G. Grant, S.F.A. Hakonarson, H. Ferrucci, L. Scott, R.A. Morris, A.D. Palmer, C.N.A. Dedoussis, G. Deloukas, P. Bertram, L. Lindenberger, U. Berndt, S.I. Lindgren, C.M. Timpson, N.J. Tönjes, A. Munroe, P.B. Sorensen, T.I.A. Rotimi, C.N. Arnett, D.K. Oldehinkel, A.J. Kardia, S.L.R. Balkau, B. Gambaro, G. Morris, A.P. Eriksson, J.G. Wright, M.J. Martin, N.G. Hunt, S.C. Starr, J.M. Deary, I.J. Griffiths, L.R. Tiemeier, H. Pirastu, N. Kaprio, J. Wareham, N.J. Pérusse, L. Wilson, J.G. Girotto, G. Caulfield, M.J. Raitakari, O. Boomsma, D.I. Gieger, C. van der Harst, P. Hicks, A.A. Kraft, P. Sinisalo, J. Knekt, P. Johannesson, M. Magnusson, P.K.E. Hamsten, A. Schmidt, R. Borecki, I.B. Vartiainen, E. Becker, D.M. Bharadwaj, D. Mohlke, K.L. Boehnke, M. van Duijn, C.M. Sanghera, D.K. Teumer, A. Zeggini, E. Metspalu, A. Gasparini, P. Ulivi, S. Ober, C. Toniolo, D. Rudan, I. Porteous, D.J. Ciullo, M. Spector, T.D. Hayward, C. Dupuis, J. Loos, R.J.F. Wright, A.F. Chandak, G.R. Vollenweider, P. Shuldiner, A.R. Ridker, P.M. Rotter, J.I. Sattar, N. Gyllensten, U. North, K.E. Pirastu, M. Psaty, B.M. Weir, D.R. Laakso, M. Gudnason, V. Takahashi, A. Chambers, J.C. Kooner, J.S. Strachan, D.P. Campbell, H. Hirschhorn, J.N. Perola, M. Polasek, O. Wilson, J.F.
Dokumenttyp:	Artikel
Erscheinungsdatum:	2015
Reihe/Periodikum:	Joshi , P K , Esko , T , Mattsson , H , Eklund , N , Gandin , I , Nutile , T , Jackson , A U , Schurmann , C , Smith , A V , Zhang , W , Okada , Y , Stancáková , A , Faul , J D , Zhao , W , Bartz , T M , Pina Concas , M , Franceschini , N , Enroth , S , Vitart , V , Trompet , S , Guo , X , Chasman , D I , O'Connel , J R , Corre , T , Nongmaithem , S S , Chen , Y , Mangino , M , Ruggiero , D , Traglia , M , Farmaki , A-E , Kacprowski , T , Bjonnes , A , Spek , A , Wu , Y , Giri , A K , Yanek , L R , Wang , L , Hofer , E , Rietveld , C A , McLeod , O , Cornelis , M C , Pattaro , C , Verweij , N , Baumbach , C , Abdellaoui , A , Warren , H R , Vuckovic , D , Mei , H , Bouchard , C , Perry , J R B , Cappellani , S , Mirza , S S , Benton , M C , Broeckel , U , Medland , S E , Lind , P A , Malerba , G , Drong , A , Yengo , L , Bielak , L F , Zhi , D , van der Most , P J , Shriner , D , Mägi , R , Hemani , G , Karaderi , T , Wang , Z , Liu , T , Demuth , I , Zhao , J H , Meng , W , Lataniotis , L , van der Laan , S W , Brafdfield , J P , Wood , A R , Bonnefond , A , Ahluwalia , T S , Hall , L M , Salvi , E , Yazar , S , Carstensen , L , de Haan , H G , Abney , M , Afzal , U , Allison , M A , Amin , N , Asselbergs , F W , Bakker , S J L , Barr , R G , Baumeister , S E , Benjamin , D J , Bergmann , S , Boerwinkle , E , Bottinger , E P , Campbell , A , Chakravarti , A , Chan , Y , Chanock , S J , Chen , C , Chen , Y D I , Colins , F S , Connell , J , Correa , A , Cupples , L A , Davey Smith , G , Davies , G , Dörr , M , Ehret , G , Ellis , S B , Feenstra , B , Feitosa , M F , Ford , I , Fox , C S , Frayling , T M , Friedrich , N , Geller , F , Gillham-Nasenya , I , Gottesman , O , Graff , M , Grodstein , F , Gu , C , Haley , C , Hammond , C J , Harris , S E , Harris , T B , Hastie , N D , Heard-Costa , N L , Heikkilä , K , Hocking , L J , Homuth , G , Hottenga , J J , Huang , J , Huffman , J E , Hysi , P G , Arfan Ikram , M , Ingelsson , E , Joensuu , A , Johansson , A , Jousilahti , P , Jukema , J W , Kähönen , M , Kamatani , Y , Kanoni , S , Kerr , S M , Khan , N M , Koellinger , P , Koistinen , H A , Kooner , M K , Kubo , M , Kuusisto , J , Lahti , J , Launer , L J , Lea , R A , Lehne , B , Lehtimäki , T , Liewald , D C M , Lind , L , Loh , M , Lokki , M L , London , S J , Loomis , S J , Loukola , A , Lu , Y , Lumley , T , Lundqvist , A , Männistö , S , Marques-Vidal , P , Masciullo , C , Matchan , A , Mathias , R A , Matsuda , K , Meigs , J B , Meisinger , C , Meitinger , T , Menni , C , Mentch , F D , Mihailov , E , Milani , L , Montasser , M E , Montgomery , G W , Morrison , A , Myers , R H , Nadukuru , R , Navarro , P , Nelis , M , Nieminen , M S , Nolte , I M , O'Connor , G T , Ogunniyi , A , Padmanabhan , S , Palmas , W R , Pankow , J S , Patarcic , I , Pavani , F , Peyser , P A , Pietilainen , K H , Poulter , N , Prokopenko , I , Ralhan , S , Redmond , P , Rich , S S , Rissanen , H , Robino , A , Rose , L M , Rose , R , Sala , C , Salako , B , Salomaa , V , Sarin , A-P , Saxena , R , Schmidt , H , Scott , L J , Scott , W R , Sennblad , B , Seshadri , S , Sever , P , Shrestha , S , Smith , B H , Smith , J A , Soranzo , N , Sotoodehnia , N , Southam , L , Stanton , A V , Stathopoulou , M G , Strauch , K , Strawbridge , R J , Suderman , M J , Tandon , N , Tang , S T , Taylor , K D , Tayo , B O , Töglhofer , A M , Tomaszewski , M , Tsernikova , N , Tuomilehto , J , Uitterlinden , A G , Vaidya , D , Hylckama Vlieg , A , van Setten , J , Vasankari , T , Vedantam , S , Vlachopoulou , E , Vozzi , D , Vuoksimaa , E , Waldenberger , M , Ware , E B , Wentworth-Shields , W , Whitfield , J B , Wild , S , Willemsen , G , Yajnik , C S , Yao , J , Zaza , G , Zhu , X , Salem , R M , Melbye , M , Bisgaard , H , Samani , N J , Cusi , D , Mackey , D A , Cooper , R S , Froguel , P , Pasterkamp , G , Grant , S F A , Hakonarson , H , Ferrucci , L , Scott , R A , Morris , A D , Palmer , C N A , Dedoussis , G , Deloukas , P , Bertram , L , Lindenberger , U , Berndt , S I , Lindgren , C M , Timpson , N J , Tönjes , A , Munroe , P B , Sorensen , T I A , Rotimi , C N , Arnett , D K , Oldehinkel , A J , Kardia , S L R , Balkau , B , Gambaro , G , Morris , A P , Eriksson , J G , Wright , M J , Martin , N G , Hunt , S C , Starr , J M , Deary , I J , Griffiths , L R , Tiemeier , H , Pirastu , N , Kaprio , J , Wareham , N J , Pérusse , L , Wilson , J G , Girotto , G , Caulfield , M J , Raitakari , O , Boomsma , D I , Gieger , C , van der Harst , P , Hicks , A A , Kraft , P , Sinisalo , J , Knekt , P , Johannesson , M , Magnusson , P K E , Hamsten , A , Schmidt , R , Borecki , I B , Vartiainen , E , Becker , D M , Bharadwaj , D , Mohlke , K L , Boehnke , M , van Duijn , C M , Sanghera , D K , Teumer , A , Zeggini , E , Metspalu , A , Gasparini , P , Ulivi , S , Ober , C , Toniolo , D , Rudan , I , Porteous , D J , Ciullo , M , Spector , T D , Hayward , C , Dupuis , J , Loos , R J F , Wright , A F , Chandak , G R , Vollenweider , P , Shuldiner , A R , Ridker , P M , Rotter , J I , Sattar , N , Gyllensten , U , North , K E , Pirastu , M , Psaty , B M , Weir , D R , Laakso , M , Gudnason , V , Takahashi , A , Chambers , J C , Kooner , J S , Strachan , D P , Campbell , H , Hirschhorn , J N , Perola , M , Polasek , O & Wilson , J F 2015 , ' Directional dominance on stature and cognition in diverse human populations ' , Nature , vol. 523 , no. 7561 , pp. 459-462 . https://doi.org/10.1038/nature14618
Schlagwörter:	/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR)
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-29213833
Datenquelle:	BASE; Originalkatalog
Powered By:	BASE
Link(s) :	https://research.vu.nl/en/publications/5931ba85-caf3-4e2e-bed3-8367f5e87273

Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power. Here we use runs of homozygosity to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts, and find statistically significant associations between summed runs of homozygosity and four complex traits: height, forced expiratory lung volume in one second, general cognitive ability and educational attainment (P < 1 × 10