Genome-wide association studies have identified hundreds of genetic variants associated with blood pressure (BP), but sequence variation accounts for a small fraction of the phenotypic variance. Epigenetic changes may alter the expression of genes involved in BP regulation and explain part of the missing heritability. We therefore conducted a two-stage meta-analysis of the cross-sectional associations of systolic and diastolic BP with blood-derived genome-wide DNA methylation measured on the Infinium HumanMethylation450 BeadChip in 17,010 individuals of European, African American, and Hispanic... Mehr ...
| Verfasser: |
Richard, Melissa A
Huan, Tianxiao
Ligthart, Symen
Gondalia, Rahul
Jhun, Min A
Brody, Jennifer A
Irvin, Marguerite R
Marioni, Riccardo
Shen, Jincheng
Tsai, Pei-Chien
Montasser, May E
Jia, Yucheng
Syme, Catriona
Salfati, Elias L
Boerwinkle, Eric
Guan, Weihua
Mosley, Thomas H
Bressler, Jan
Morrison, Alanna C
Liu, Chunyu
Mendelson, Michael M
Uitterlinden, André G
van Meurs, Joyce B
Franco, Oscar H
Zhang, Guosheng
Li, Yun
Stewart, James D
Bis, Joshua C
Psaty, Bruce M
Chen, Yii-Der Ida
Kardia, Sharon L R
Zhao, Wei
Turner, Stephen T
Absher, Devin
Aslibekyan, Stella
Starr, John M
McRae, Allan F
Hou, Lifang
Just, Allan C
Schwartz, Joel D
Vokonas, Pantel S
Menni, Cristina
Spector, Tim D
Shuldiner, Alan
Damcott, Coleen M
Rotter, Jerome I
Boomsma, D.I.
Pool, R.
van Dongen, J.
Hottenga, J.J. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2017 |
| Reihe/Periodikum: |
Richard , M A , Huan , T , Ligthart , S , Gondalia , R , Jhun , M A , Brody , J A , Irvin , M R , Marioni , R , Shen , J , Tsai , P-C , Montasser , M E , Jia , Y , Syme , C , Salfati , E L , Boerwinkle , E , Guan , W , Mosley , T H , Bressler , J , Morrison , A C , Liu , C , Mendelson , M M , Uitterlinden , A G , van Meurs , J B , Franco , O H , Zhang , G , Li , Y , Stewart , J D , Bis , J C , Psaty , B M , Chen , Y-D I , Kardia , S L R , Zhao , W , Turner , S T , Absher , D , Aslibekyan , S , Starr , J M , McRae , A F , Hou , L , Just , A C , Schwartz , J D , Vokonas , P S , Menni , C , Spector , T D , Shuldiner , A , Damcott , C M , Rotter , J I , BIOS Consortium , Boomsma , D I , Pool , R , van Dongen , J & Hottenga , J J 2017 , ' DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation ' , American Journal of Human Genetics , vol. 101 , no. 6 , pp. 888-902 . https://doi.org/10.1016/j.ajhg.2017.09.028 |
| Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29213775 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/51b0b3db-be77-422d-8855-2ee913d5b802 |
