Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

The genetic contribution to the variation in human lifespan is ~25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent (≥85 years) and 16 121 younger controls (<65 years) followed by replication in an additional set of 13 060 long-lived individuals and 61 156 controls. In addition, we performed a subset analysis in cases aged ≥90 years. We observed genomewide significant association with longevity, as reflected b... Mehr ...

Verfasser:	Deelen, J. Beekman, M. Uh, H.W. Broer, L. Ayers, K.L. Tan, Q. Kamatani, Y. Bennet, A.M. Tamm, R. Trompet, S. Gudbjartsson, D.F. Flachsbart, F. Rose, G. Viktorin, A. Fischer, K. Nygaard, M. Cordell, H.J. Crocco, P. van den Akker, E.B. Böhringer, S. Helmer, Q. Nelson, C.P. Saunders, G.I. Alver, M. Andersen-Ranberg, K. Breen, M.E. van der Breggen, R. Caliebe, A. Capri, M. Cevenini, E. Collerton, J.C. Dato, S. Davies, K. Ford, I. Gampe, J. Garagnani, P. de Geus, E.J.C. Harrow, J. van Heemst, D. Heijmans, B.T. Heinsen, F.A. Hottenga, J.J. Hofman, A. Jeune, B. Jonsson, P.V. Lathrop, M. Lechner, D. Martin-Ruiz, C. McNerlan, S.E. Mihailov, E. Montesanto, A. Mooijaart, S.P. Murphy, A. Nohr, E.A. Paternoster, L. Postmus, I. Rivadeneira, F. Ross, O.A. Salvioli, S. Sattar, N. Schreiber, S Stefansson, H. Stott, D.J. Tiemeier, H. Uitterlinden, A.G. Westendorp, R.G.J. Willemsen, G. Samani, N.J. Galan, P. Sørensen, T.I.A. Boomsma, D.I. Jukema, J.W. Maeve Rea, I. Passarino, G. de Craen, A.J. Christensen, K. Nebel, A. Stefansson, K. Metspalu, A. Magnusson, P. Blanché, H. Christiansen, L. Kirkwood, T.B.L. van Duijn, C.M. Franceschi, C. Houwing-Duistermaat, J.J. Slagboom, P.E.
Dokumenttyp:	Artikel
Erscheinungsdatum:	2014
Reihe/Periodikum:	Deelen , J , Beekman , M , Uh , H W , Broer , L , Ayers , K L , Tan , Q , Kamatani , Y , Bennet , A M , Tamm , R , Trompet , S , Gudbjartsson , D F , Flachsbart , F , Rose , G , Viktorin , A , Fischer , K , Nygaard , M , Cordell , H J , Crocco , P , van den Akker , E B , Böhringer , S , Helmer , Q , Nelson , C P , Saunders , G I , Alver , M , Andersen-Ranberg , K , Breen , M E , van der Breggen , R , Caliebe , A , Capri , M , Cevenini , E , Collerton , J C , Dato , S , Davies , K , Ford , I , Gampe , J , Garagnani , P , de Geus , E J C , Harrow , J , van Heemst , D , Heijmans , B T , Heinsen , F A , Hottenga , J J , Hofman , A , Jeune , B , Jonsson , P V , Lathrop , M , Lechner , D , Martin-Ruiz , C , McNerlan , S E , Mihailov , E , Montesanto , A , Mooijaart , S P , Murphy , A , Nohr , E A , Paternoster , L , Postmus , I , Rivadeneira , F , Ross , O A , Salvioli , S , Sattar , N , Schreiber , S , Stefansson , H , Stott , D J , Tiemeier , H , Uitterlinden , A G , Westendorp , R G J , Willemsen , G , Samani , N J , Galan , P , Sørensen , T I A , Boomsma , D I , Jukema , J W , Maeve Rea , I , Passarino , G , de Craen , A J , Christensen , K , Nebel , A , Stefansson , K , Metspalu , A , Magnusson , P , Blanché , H , Christiansen , L , Kirkwood , T B L , van Duijn , C M , Franceschi , C , Houwing-Duistermaat , J J & Slagboom , P E 2014 , ' Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age ' , Human Molecular Genetics , vol. 23 , no. 16 , pp. 4420-4432 . https://doi.org/10.1093/hmg/ddu139
Schlagwörter:	/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-29213432
Datenquelle:	BASE; Originalkatalog
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Link(s) :	https://research.vu.nl/en/publications/224798d2-8125-4f1e-b937-cc59070e34f7