Genetic risk factors often localize to noncoding regions of the genome with unknown effects on disease etiology. Expression quantitative trait loci (eQTLs) help to explain the regulatory mechanisms underlying these genetic associations. Knowledge of the context that determines the nature and strength of eQTLs may help identify cell types relevant to pathophysiology and the regulatory networks underlying disease. Here we generated peripheral blood RNA-seq data from 2,116 unrelated individuals and systematically identified context-dependent eQTLs using a hypothesis-free strategy that does not re... Mehr ...
| Verfasser: |
Zhernakova, Daria V
Deelen, Patrick
Vermaat, Martijn
van Iterson, Maarten
van Galen, Michiel
Arindrarto, Wibowo
van 't Hof, Peter
Mei, Hailiang
van Dijk, Freerk
Westra, Harm-Jan
Bonder, Marc Jan
van Rooij, Jeroen
Verkerk, Marijn
Jhamai, P Mila
Moed, Matthijs
Kielbasa, Szymon M
Bot, Jan
Nooren, Irene
Pool, René
van Dongen, J.
Hottenga, Jouke J
Stehouwer, Coen D A
van der Kallen, Carla J H
Schalkwijk, Casper G
Zhernakova, Alexandra
Li, Yang
Tigchelaar, Ettje F
de Klein, Niek
Beekman, Marian
Deelen, Joris
van Heemst, Diana
van den Berg, Leonard H
Hofman, Albert
Uitterlinden, André G
Van Greevenbroek, Marleen J.
Veldink, Jan H
Boomsma, Dorret I
van Duijn, Cornelia M
Wijmenga, Cisca
Slagboom, P. Eline
Swertz, Morris a.
Isaacs, Aaron
van Meurs, Joyce B J
Jansen, Rick
Heijmans, Bastiaan T
’t Hoen, Peter a.C
Franke, Lude |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2017 |
| Reihe/Periodikum: |
Zhernakova , D V , Deelen , P , Vermaat , M , van Iterson , M , van Galen , M , Arindrarto , W , van 't Hof , P , Mei , H , van Dijk , F , Westra , H-J , Bonder , M J , van Rooij , J , Verkerk , M , Jhamai , P M , Moed , M , Kielbasa , S M , Bot , J , Nooren , I , Pool , R , van Dongen , J , Hottenga , J J , Stehouwer , C D A , van der Kallen , C J H , Schalkwijk , C G , Zhernakova , A , Li , Y , Tigchelaar , E F , de Klein , N , Beekman , M , Deelen , J , van Heemst , D , van den Berg , L H , Hofman , A , Uitterlinden , A G , Van Greevenbroek , M J , Veldink , J H , Boomsma , D I , van Duijn , C M , Wijmenga , C , Slagboom , P E , Swertz , M A , Isaacs , A , van Meurs , J B J , Jansen , R , Heijmans , B T , ’t Hoen , P A C & Franke , L 2017 , ' Identification of context-dependent expression quantitative trait loci in whole blood ' , Nature Genetics , vol. 49 , no. 1 , pp. 139-145 . https://doi.org/10.1038/ng.3737 |
| Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29213403 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/1ec4fef5-1e46-4768-90b0-3c06372d52cb |
