Combined association and linkage analysis applied to the APOE locus.
Combined association and linkage analysis is a powerful tool for pinpointing functional quantitative traits (QTLs) responsible for regions of significant linkage identified in genome-wide scans. We applied this technique to apoE plasma levels and the APOEε2/ε3/ε4 polymorphism in two Dutch twin cohorts of different age ranges. Across chromosome 19, short tandem repeats and the APOEε2/ε3/ε4 polymorphism were genotyped in adolescent (aged 13-22 years) and adult (aged 34-62 years) Dutch twins. In both samples, evidence for indicative linkage with plasma apoE levels was found (maximum LOD score (ML... Mehr ...
| Verfasser: |
Beekman, M.
Posthuma, D.
Heijmans, B.T.
Lakenberg, N.
Suchiman, H.E.D.
Snieder, H.
de Knijff, P.
Frants, R.R.
van Ommen, G.J.B
Kluft, C.
Vogler, G.P.
Slagboom, P.E.
Boomsma, D.I. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2004 |
| Reihe/Periodikum: |
Beekman , M , Posthuma , D , Heijmans , B T , Lakenberg , N , Suchiman , H E D , Snieder , H , de Knijff , P , Frants , R R , van Ommen , G J B , Kluft , C , Vogler , G P , Slagboom , P E & Boomsma , D I 2004 , ' Combined association and linkage analysis applied to the APOE locus. ' , Genetic Epidemiology , vol. 26 , no. 4 , pp. 328-337 . https://doi.org/10.1002/gepi.10318 |
| Schlagwörter: |
/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
/ name=SDG 3 - Good Health and Well-being |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29213131 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/05329cda-c83e-4400-936e-08ac032ba12a |
