Low prevalence of male microchimerism in women with Mayer-Rokitansky-Küster-Hauser syndrome
STUDY QUESTION: Is there an increased prevalence of male microchimerism in women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, as evidence of fetal exposure to blood and anti-Müllerian hormone (AMH) from a (vanished) male co-twin resulting in regression of the Müllerian duct derivatives? SUMMARY ANSWER: Predominant absence of male microchimerism in adult women with MRKH syndrome does not support our hypothesis that intrauterine blood exchange with a (vanished) male co-twin is the pathophysiological mechanism. WHAT IS KNOWN ALREADY: The etiology of MRKH is unclear. Research on the phenot... Mehr ...
| Verfasser: |
Peters, H. E.
Johnson, B. N.
Ehli, E. A.
Micha, D.
Verhoeven, M. O.
Davies, G. E.
Dekker, J. J.M.L.
Overbeek, A.
Berg, M. H.van den
Dulmen-den Broeder, E. van
Leeuwen, F. E.van
Mijatovic, V.
Boomsma, D. I.
Lambalk, C. B. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2019 |
| Reihe/Periodikum: |
Peters , H E , Johnson , B N , Ehli , E A , Micha , D , Verhoeven , M O , Davies , G E , Dekker , J J M L , Overbeek , A , Berg , M H V D , Dulmen-den Broeder , E V , Leeuwen , F E V , Mijatovic , V , Boomsma , D I & Lambalk , C B 2019 , ' Low prevalence of male microchimerism in women with Mayer-Rokitansky-Küster-Hauser syndrome ' , Human Reproduction , vol. 34 , no. 6 , dez044 , pp. 1117-1125 . https://doi.org/10.1093/humrep/dez044 |
| Schlagwörter: |
Mayer–Rokitansky–Küster–Hauser syndrome
/ Müllerian aplasia
/ etiology
/ freemartinism
/ microchimerism
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR) |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29212774 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/d76f61ee-a5ff-47d5-b7b0-481322a0e10a |
