BACKGROUND: The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS × CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample. METHODS: Data were combined from 3024 MDD cases and 2741 control... Mehr ...
| Verfasser: |
Peyrot, Wouter J
Van der Auwera, Sandra
Milaneschi, Yuri
Dolan, Conor V
Madden, Pamela A F
Sullivan, Patrick F
Strohmaier, Jana
Ripke, Stephan
Rietschel, Marcella
Nivard, Michel G
Mullins, Niamh
Montgomery, Grant W
Henders, Anjali K
Heat, Andrew C
Fisher, Helen L
Dunn, Erin C
Byrne, Enda M
Air, Tracy A
Baune, Bernhard T
Breen, Gerome
Levinson, Douglas F
Lewis, Cathryn M
Martin, Nick G
Nelson, Elliot N
Boomsma, Dorret I
Grabe, Hans J
Wray, Naomi R
Penninx, Brenda W J H
Hottenga, J.J. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2018 |
| Reihe/Periodikum: |
Peyrot , W J , Van der Auwera , S , Milaneschi , Y , Dolan , C V , Madden , P A F , Sullivan , P F , Strohmaier , J , Ripke , S , Rietschel , M , Nivard , M G , Mullins , N , Montgomery , G W , Henders , A K , Heat , A C , Fisher , H L , Dunn , E C , Byrne , E M , Air , T A , Baune , B T , Breen , G , Levinson , D F , Lewis , C M , Martin , N G , Nelson , E N , Boomsma , D I , Grabe , H J , Wray , N R , Penninx , B W J H , Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & Hottenga , J J 2018 , ' Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium ' , Biological Psychiatry , vol. 84 , no. 2 , pp. 138-147 . https://doi.org/10.1016/j.biopsych.2017.09.009 |
| Schlagwörter: |
Journal Article
/ /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_
/ name=Netherlands Twin Register (NTR)
/ /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions
/ name=SDG 16 - Peace
/ Justice and Strong Institutions |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29212743 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://research.vu.nl/en/publications/d4187cbd-d698-4114-a710-1a128672b906 |
