Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Verfasser:	Nolte, Ilja M Munoz, M Loretto Tragante, Vinicius Amare, Azmeraw T Jansen, Rick Vaez, Ahmad von der Heyde, Benedikt Avery, Christy L Bis, Joshua C Dierckx, Bram van Dongen, Jenny Gogarten, Stephanie M Goyette, Philippe Hernesniemi, Jussi Huikari, Ville Hwang, Shih-Jen Jaju, Deepali Kerr, Kathleen F Kluttig, Alexander Krijthe, Bouwe P Kumar, Jitender van der Laan, Sander W Lyytikäinen, Leo-Pekka Maihofer, Adam X Minassian, Arpi van der Most, Peter J Müller-Nurasyid, Martina Nivard, Michel Salvi, Erika Stewart, James D Thayer, Julian F Verweij, Niek Wong, Andrew Zabaneh, Delilah Zafarmand, Mohammad H Abdellaoui, Abdel Albarwani, Sulayma Albert, Christine Alonso, Alvaro Ashar, Foram Auvinen, Juha Axelsson, Tomas Baker, Dewleen G de Bakker, Paul I W Barcella, Matteo Bayoumi, Riad Bieringa, Rob J Boomsma, Dorret Boucher, Gabrielle Britton, Annie R Christophersen, Ingrid Dietrich, Andrea Ehret, George B Ellinor, Patrick T Eskola, Markku Felix, Janine F Floras, John S Franco, Oscar H Friberg, Peter Gademan, Maaike G J Geyer, Mark A Giedraitis, Vilmantas Hartman, Catharina A Hemerich, Daiane Hofman, Albert Hottenga, Jouke-Jan Huikuri, Heikki Hutri-Kähönen, Nina Jouven, Xavier Junttila, Juhani Juonala, Markus Kiviniemi, Antti M Kors, Jan A. Kumari, Meena Kuznetsova, Tatiana Laurie, Cathy C Lefrandt, Joop D. Li, Yong Li, Yun Liao, Duanping Limacher, Marian C Lin, Henry J Lindgren, Cecilia M Lubitz, Steven A Mahajan, Anubha McKnight, Barbara Zu Schwabedissen, Henriette Meyer Milaneschi, Yuri Mononen, Nina Morris, Andrew P Nalls, Mike A Navis, Gerjan Neijts, Melanie Nikus, Kjell North, Kari E O'Connor, Daniel T Ormel, Johan Perz, Siegfried Peters, Annette Psaty, Bruce M Raitakari, Olli T Risbrough, Victoria B Sinner, Moritz F Siscovick, David Smit, Johannes H Smith, Nicholas L Soliman, Elsayed Z Sotoodehnia, Nona Staessen, Jan A Stein, Phyllis K Stilp, Adrienne M Stolarz-Skrzypek, Katarzyna Strauch, Konstantin Sundström, Johan Swenne, Cees A. Syvänen, Ann-Christine Tardif, Jean-Claude Taylor, Kent D Teumer, Alexander Thornton, Timothy A Tinker, Lesley E Uitterlinden, André G van Setten, Jessica Voss, Andreas Waldenberger, Melanie Wilhelmsen, Kirk C Willemsen, Gonneke Wong, Quenna Zhang, Zhu-Ming Zonderman, Alan B Cusi, Daniele Evans, Michele K Greiser, Halina K van der Harst, Pim Hassan, Mohammad Ingelsson, Erik Järvelin, Marjo-Riitta Kääb, Stefan Kähönen, Mika Kivimaki, Mika Kooperberg, Charles Kuh, Diana Lehtimäki, Terho Lind, Lars Nievergelt, Caroline M O'Donnell, Chris J Oldehinkel, Albertine J Penninx, Brenda Reiner, Alexander P Riese, Harriëtte Van Roon, Arie M. Rioux, John D Rotter, Jerome I Sofer, Tamar Stricker, Bruno H Tiemeier, Henning Vrijkotte, Tanja G M Asselbergs, Folkert W Brundel, Bianca J J M Heckbert, Susan R Whitsel, Eric A den Hoed, Marcel Snieder, Harold de Geus, Eco J C
Dokumenttyp:	Artikel
Erscheinungsdatum:	2017
Reihe/Periodikum:	Nolte , I M , Munoz , M L , Tragante , V , Amare , A T , Jansen , R , Vaez , A , von der Heyde , B , Avery , C L , Bis , J C , Dierckx , B , van Dongen , J , Gogarten , S M , Goyette , P , Hernesniemi , J , Huikari , V , Hwang , S-J , Jaju , D , Kerr , K F , Kluttig , A , Krijthe , B P , Kumar , J , van der Laan , S W , Lyytikäinen , L-P , Maihofer , A X , Minassian , A , van der Most , P J , Müller-Nurasyid , M , Nivard , M , Salvi , E , Stewart , J D , Thayer , J F , Verweij , N , Wong , A , Zabaneh , D , Zafarmand , M H , Abdellaoui , A , Albarwani , S , Albert , C , Alonso , A , Ashar , F , Auvinen , J , Axelsson , T , Baker , D G , de Bakker , P I W , Barcella , M , Bayoumi , R , Bieringa , R J , Boomsma , D , Boucher , G , Britton , A R , Christophersen , I , Dietrich , A , Ehret , G B , Ellinor , P T , Eskola , M , Felix , J F , Floras , J S , Franco , O H , Friberg , P , Gademan , M G J , Geyer , M A , Giedraitis , V , Hartman , C A , Hemerich , D , Hofman , A , Hottenga , J-J , Huikuri , H , Hutri-Kähönen , N , Jouven , X , Junttila , J , Juonala , M , Kiviniemi , A M , Kors , J A , Kumari , M , Kuznetsova , T , Laurie , C C , Lefrandt , J D , Li , Y , Li , Y , Liao , D , Limacher , M C , Lin , H J , Lindgren , C M , Lubitz , S A , Mahajan , A , McKnight , B , Zu Schwabedissen , H M , Milaneschi , Y , Mononen , N , Morris , A P , Nalls , M A , Navis , G , Neijts , M , Nikus , K , North , K E , O'Connor , D T , Ormel , J , Perz , S , Peters , A , Psaty , B M , Raitakari , O T , Risbrough , V B , Sinner , M F , Siscovick , D , Smit , J H , Smith , N L , Soliman , E Z , Sotoodehnia , N , Staessen , J A , Stein , P K , Stilp , A M , Stolarz-Skrzypek , K , Strauch , K , Sundström , J , Swenne , C A , Syvänen , A-C , Tardif , J-C , Taylor , K D , Teumer , A , Thornton , T A , Tinker , L E , Uitterlinden , A G , van Setten , J , Voss , A , Waldenberger , M , Wilhelmsen , K C , Willemsen , G , Wong , Q , Zhang , Z-M , Zonderman , A B , Cusi , D , Evans , M K , Greiser , H K , van der Harst , P , Hassan , M , Ingelsson , E , Järvelin , M-R , Kääb , S , Kähönen , M , Kivimaki , M , Kooperberg , C , Kuh , D , Lehtimäki , T , Lind , L , Nievergelt , C M , O'Donnell , C J , Oldehinkel , A J , Penninx , B , Reiner , A P , Riese , H , Van Roon , A M , Rioux , J D , Rotter , J I , Sofer , T , Stricker , B H , Tiemeier , H , Vrijkotte , T G M , Asselbergs , F W , Brundel , B J J M , Heckbert , S R , Whitsel , E A , den Hoed , M , Snieder , H & de Geus , E J C 2017 , ' Genetic loci associated with heart rate variability and their effects on cardiac disease risk ' , Nature Communications , vol. 8 , 15805 , pp. 15805 . https://doi.org/10.1038/ncomms15805
Schlagwörter:	Journal Article / /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-29212432
Datenquelle:	BASE; Originalkatalog
Powered By:	BASE
Link(s) :	https://research.vu.nl/en/publications/b0a16bb0-90a6-4d7d-b620-0643cf7f7780

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74<rg<-0.55) and blood pressure (-0.35<rg<-0.20). These findings provide clinically relevant biological insight into heritable variation in vagal heart rhythm regulation, with a key role for genetic variants (GNG11, RGS6) that influence G-protein heterotrimer action in GIRK-channel induced pacemaker membrane hyperpolarization.