Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth pubertal timing and childhood adiposity

The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growthfactors.Although little is knownabout the underlying genetics,growthvariabilityduring puberty correlates with adult risks for hormone-dependent cancer and adverse cardiometabolic health. The only gene so far associatedwith pubertal height growth, LIN28B, pleiotropically influences childhood growth, puberty and cancer progression, pointing to shared underlyingmechanisms. To discover genetic loci influencing pubertal height and growth and to place them in con... Mehr ...

Verfasser:	Cousminer, D.L. Berry, D.J. Timpson, N.J. Ang, W. Thiering, E. Byrne, E.M. Taal, H.R. Huikari, V. Bradfield, J.P. Kerkhof, M. Groen-Blokhuis, M.M. Kreiner-Møller, E. Marinelli, M. Holst, C. Leinonen, J.T. Perry, J.R. Surakka, I. Pietilainen, O.P. Kettunen, J. Anttila, V. Kaakinen, M. Sovio, U. Pouta, A. Das, S. Lagou, V. Power, C. Prokopenko, I. Evans, D.M. Kemp, J.P. St Pourcain, B. Ring, S.M. Palotie, A. Kajantie, E. Osmond, C. Lehtimäki, T. Viikari, J.S. Kähönen, M. Warrington, N.M. Lye, S.J. Palmer, L.J. Tiesler, C.M.T. Flexeder, C. Montgomery, G.W. Medland, S.E. Hofman, A. Hakonarson, H. Guxens, M. Bartels, M. Salomaa, V. Adair, L.S. Atalay, M. van Beijsterveldt, C.E.M. Bergen, N. Benke, K.S. Charoen, P. Coin, L. Cooper, C. Davis, O.S. Dedoussis, G.V. Elliott, P. Estivill, X. Feenstra, B. Frayling, T.M. Freathy, R.M. Gaillard, R. Geller, F. Gillman, M.W. Goh, L.K. Hattersley, A.T. Haworth, C.M. Hadley, D. Hedebrand, J. Hinney, A. Hirschhorn, J.N. Hocher, B. Holloway, J.W. Hottenga, J.J. Horikoshi, M. Iñiguez, C. Järvelin, M.R. Kilpeläinen, T.O. Kirin, M. Kowgier, M. Lakka, H.M. Lakka, T.A. Lange, L.A. Lawlor, D.A. Lewin, A. Lindgren, C.M. Lindi, V. Maggi, R. Marsh, J. Melbye, M. Middeldorp, C.M. Millwood, I. Mohlke, K.L. Mook-Kanamori, D.O. Murray, J.C. Nivard, M.G. Nohr, E.A. Ntalla, I. Oken, E. Ong, K.K. O'Reilly, P.F. Panoutsopoulou, K. Pararajasingham, J. Pearson, E.R. Price, T.S. Rodriguez, A. Salem, R.M. Saw, S.M. Scherag, A. Sebert, S. Siitonen, N. Simell, O. Strachan, D.P. Sunyer, J. Teo, Y.Y. Uitterlinden, A.G. Valcárcel, B. White, S. Widén, E. Willemsen, G. Wilson, J.F. Yaghootkar, H. Zeggini, E. Elks, C.E. Sulem, P. Chasman, D.I. Franceschini, N. He, C. Lunetta, K.L. Visser, J.A. Gudbjartsson, D.F. Esko, T. Koller, D.L. Kutalik, Z. Lin, P. Mangino, M. Marongiu, M. McArdle, P.F. Smith, A.V. Stolk, L. van Wingerden, S. Zhao, J.H. Albrecht, E. Corre, T. Ingelsson, E. Hayward, C. Magnusson, P.K.E. Smith, E.N. Ulivi, S. Warrington, M. Zgaga, L. Alavere, H. Amin, N. Aspelund, T. Bandinelli, S. Barroso, I. Berenson, G.S. Bergmann, S. Blackburn, H. Boerwinkle, E. Buring, J.E. Busonero, F. Campbell, H. Chanock, S.J. Chen, W. Cornelis, M.C. Couper, D. Coviello, A.D. d'Adamo, P. de Faire, U. de Geus, E.J.C. Deloukas, P. Döring, A. Davey Smith, G. Easton, D.F. Eiriksdottir, G. Emilsson, V. Ferrucci, L. Folsom, A.R. Foroud, T. Garcia, M. Gasparini, P. Gieger, C. Gudnason, V. Hall, P. Hankinson, S.E. Ferreli, L. Heath, A.C. Hernandez, D.G. Hu, F.B. Illig, T. Johnson, A.D. Karasik, D. Khaw, K.T. Kiel, D.P. Kolcic, I. Kraft, P. Launer, L.J. Laven, J.S. Li, S. Liu, J. Levy, D. McArdle, W.L. Mooser, V. Murray, S.S. Nalls, M.A. Navarro, P. Nelis, M. Ness, A.R. Northstone, K. Oostra, B.A. Peacock, M. Paré, G. Parker, A.N. Pedersen, N.L. Peltonen, L. Pennell, C.E. Pharoah, P. Polasek, O. Plump, A.S. Porcu, E. Rafnar, T. Rice, J.P. Rivadeneira, F. Rudan, I. Sala, C. Sanna, S. Schlessinger, D. Schork, N.J. Scuteri, A. Segrè, A.V. Shuldiner, A.R. Soranzo, N. Srinivasan, S.R. Tammesoo, M.L. Tikkanen, E. Toniolo, D. Tsui, K. Tryggvadottir, L. Tyrer, J. Uda, M. Dam, R.M. van Meurs, J.B. Vollenweider, P. Waeber, G. Wareham, N.J. Waterworth, D. Weedon, M.N. Wichmann, H.E. Wright, A.F. Young, L. Zhai, G. Zhuang, W.V. Bierut, L.J. Boyd, H.A. Crisponi, L. Demerath, E.W. van Duijn, C.M. Econs, M.J. Harris, T.B. Hunter, D.J. Loos, R.J. Metspalu, A. Ridker, P.M. Spector, T.D. Streeten, E.A. Stefansson, K. Thorsteinsdottir, U. Murray, A. Murabito, J.M. Kaprio, J. Sørensen, T.I.A. Ballester, F. Bisgaard, H. Boomsma, D.I. Koppelman, G.H. Grant, S.F. Jaddoe, V.W. Martin, N.G. Heinrich, J. Raitakari, O.T. Eriksson, J.G. Smith, G.D. Hyppönen, E. McCarthy, M.I. Ripatti, S.
Dokumenttyp:	Artikel
Erscheinungsdatum:	2013
Reihe/Periodikum:	Cousminer , D L , Berry , D J , Timpson , N J , Ang , W , Thiering , E , Byrne , E M , Taal , H R , Huikari , V , Bradfield , J P , Kerkhof , M , Groen-Blokhuis , M M , Kreiner-Møller , E , Marinelli , M , Holst , C , Leinonen , J T , Perry , J R , Surakka , I , Pietilainen , O P , Kettunen , J , Anttila , V , Kaakinen , M , Sovio , U , Pouta , A , Das , S , Lagou , V , Power , C , Prokopenko , I , Evans , D M , Kemp , J P , St Pourcain , B , Ring , S M , Palotie , A , Kajantie , E , Osmond , C , Lehtimäki , T , Viikari , J S , Kähönen , M , Warrington , N M , Lye , S J , Palmer , L J , Tiesler , C M T , Flexeder , C , Montgomery , G W , Medland , S E , Hofman , A , Hakonarson , H , Guxens , M , Bartels , M , Salomaa , V , Adair , L S , Atalay , M , van Beijsterveldt , C E M , Bergen , N , Benke , K S , Charoen , P , Coin , L , Cooper , C , Davis , O S , Dedoussis , G V , Elliott , P , Estivill , X , Feenstra , B , Frayling , T M , Freathy , R M , Gaillard , R , Geller , F , Gillman , M W , Goh , L K , Hattersley , A T , Haworth , C M , Hadley , D , Hedebrand , J , Hinney , A , Hirschhorn , J N , Hocher , B , Holloway , J W , Hottenga , J J , Horikoshi , M , Iñiguez , C , Järvelin , M R , Kilpeläinen , T O , Kirin , M , Kowgier , M , Lakka , H M , Lakka , T A , Lange , L A , Lawlor , D A , Lewin , A , Lindgren , C M , Lindi , V , Maggi , R , Marsh , J , Melbye , M , Middeldorp , C M , Millwood , I , Mohlke , K L , Mook-Kanamori , D O , Murray , J C , Nivard , M G , Nohr , E A , Ntalla , I , Oken , E , Ong , K K , O'Reilly , P F , Panoutsopoulou , K , Pararajasingham , J , Pearson , E R , Price , T S , Rodriguez , A , Salem , R M , Saw , S M , Scherag , A , Sebert , S , Siitonen , N , Simell , O , Strachan , D P , Sunyer , J , Teo , Y Y , Uitterlinden , A G , Valcárcel , B , White , S , Widén , E , Willemsen , G , Wilson , J F , Yaghootkar , H , Zeggini , E , Elks , C E , Sulem , P , Chasman , D I , Franceschini , N , He , C , Lunetta , K L , Visser , J A , Gudbjartsson , D F , Esko , T , Koller , D L , Kutalik , Z , Lin , P , Mangino , M , Marongiu , M , McArdle , P F , Smith , A V , Stolk , L , van Wingerden , S , Zhao , J H , Albrecht , E , Corre , T , Ingelsson , E , Hayward , C , Magnusson , P K E , Smith , E N , Ulivi , S , Warrington , M , Zgaga , L , Alavere , H , Amin , N , Aspelund , T , Bandinelli , S , Barroso , I , Berenson , G S , Bergmann , S , Blackburn , H , Boerwinkle , E , Buring , J E , Busonero , F , Campbell , H , Chanock , S J , Chen , W , Cornelis , M C , Couper , D , Coviello , A D , d'Adamo , P , de Faire , U , de Geus , E J C , Deloukas , P , Döring , A , Davey Smith , G , Easton , D F , Eiriksdottir , G , Emilsson , V , Ferrucci , L , Folsom , A R , Foroud , T , Garcia , M , Gasparini , P , Gieger , C , Gudnason , V , Hall , P , Hankinson , S E , Ferreli , L , Heath , A C , Hernandez , D G , Hu , F B , Illig , T , Johnson , A D , Karasik , D , Khaw , K T , Kiel , D P , Kolcic , I , Kraft , P , Launer , L J , Laven , J S , Li , S , Liu , J , Levy , D , McArdle , W L , Mooser , V , Murray , S S , Nalls , M A , Navarro , P , Nelis , M , Ness , A R , Northstone , K , Oostra , B A , Peacock , M , Paré , G , Parker , A N , Pedersen , N L , Peltonen , L , Pennell , C E , Pharoah , P , Polasek , O , Plump , A S , Porcu , E , Rafnar , T , Rice , J P , Rivadeneira , F , Rudan , I , Sala , C , Sanna , S , Schlessinger , D , Schork , N J , Scuteri , A , Segrè , A V , Shuldiner , A R , Soranzo , N , Srinivasan , S R , Tammesoo , M L , Tikkanen , E , Toniolo , D , Tsui , K , Tryggvadottir , L , Tyrer , J , Uda , M , Dam , R M , van Meurs , J B , Vollenweider , P , Waeber , G , Wareham , N J , Waterworth , D , Weedon , M N , Wichmann , H E , Wright , A F , Young , L , Zhai , G , Zhuang , W V , Bierut , L J , Boyd , H A , Crisponi , L , Demerath , E W , van Duijn , C M , Econs , M J , Harris , T B , Hunter , D J , Loos , R J , Metspalu , A , Ridker , P M , Spector , T D , Streeten , E A , Stefansson , K , Thorsteinsdottir , U , Murray , A , Murabito , J M , Kaprio , J , Sørensen , T I A , Ballester , F , Bisgaard , H , Boomsma , D I , Koppelman , G H , Grant , S F , Jaddoe , V W , Martin , N G , Heinrich , J , Raitakari , O T , Eriksson , J G , Smith , G D , Hyppönen , E , McCarthy , M I & Ripatti , S 2013 , ' Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth pubertal timing and childhood adiposity ' , Human Molecular Genetics , vol. 22 , no. 13 , pp. 2735-2747 . https://doi.org/10.1093/hmg/ddt104
Schlagwörter:	/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-29212417
Datenquelle:	BASE; Originalkatalog
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Link(s) :	https://research.vu.nl/en/publications/aee60a65-1c97-4cdb-bbdf-4763f903bbe7