Associations between birth size and later height from infancy through adulthood:An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project

BACKGROUND: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. AIM: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. METHODS: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic... Mehr ...

Verfasser: Jelenkovic, Aline
Yokoyama, Yoshie
Sund, Reijo
Hur, Yoon Mi
Harris, Jennifer R.
Brandt, Ingunn
Nilsen, Thomas Sevenius
Ooki, Syuichi
Ullemar, Vilhelmina
Almqvist, Catarina
Magnusson, Patrik K.E.
Saudino, Kimberly J.
Stazi, Maria A.
Fagnani, Corrado
Brescianini, Sonia
Nelson, Tracy L.
Whitfield, Keith E.
Knafo-Noam, Ariel
Mankuta, David
Abramson, Lior
Cutler, Tessa L.
Hopper, John L.
Llewellyn, Clare H.
Fisher, Abigail
Corley, Robin P.
Huibregtse, Brooke M.
Derom, Catherine A.
Vlietinck, Robert F.
Bjerregaard-Andersen, Morten
Beck-Nielsen, Henning
Sodemann, Morten
Krueger, Robert F.
McGue, Matt
Pahlen, Shandell
Alexandra Burt, S.
Klump, Kelly L.
Dubois, Lise
Boivin, Michel
Brendgen, Mara
Dionne, Ginette
Vitaro, Frank
Willemsen, Gonneke
Bartels, Meike
van Beijsterveld, Catharina E.M.
Craig, Jeffrey M.
Saffery, Richard
Rasmussen, Finn
Tynelius, Per
Heikkilä, Kauko
Boomsma, Dorret I.
Dokumenttyp: Artikel
Erscheinungsdatum: 2018
Reihe/Periodikum: Jelenkovic , A , Yokoyama , Y , Sund , R , Hur , Y M , Harris , J R , Brandt , I , Nilsen , T S , Ooki , S , Ullemar , V , Almqvist , C , Magnusson , P K E , Saudino , K J , Stazi , M A , Fagnani , C , Brescianini , S , Nelson , T L , Whitfield , K E , Knafo-Noam , A , Mankuta , D , Abramson , L , Cutler , T L , Hopper , J L , Llewellyn , C H , Fisher , A , Corley , R P , Huibregtse , B M , Derom , C A , Vlietinck , R F , Bjerregaard-Andersen , M , Beck-Nielsen , H , Sodemann , M , Krueger , R F , McGue , M , Pahlen , S , Alexandra Burt , S , Klump , K L , Dubois , L , Boivin , M , Brendgen , M , Dionne , G , Vitaro , F , Willemsen , G , Bartels , M , van Beijsterveld , C E M , Craig , J M , Saffery , R , Rasmussen , F , Tynelius , P , Heikkilä , K & Boomsma , D I 2018 , ' Associations between birth size and later height from infancy through adulthood : An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project ' , Early Human Development , vol. 120 , pp. 53-60 . https://doi.org/10.1016/j.earlhumdev.2018.04.004
Schlagwörter: Birth length / Birth weight / Height / Ponderal index / Twins / /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR)
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29212369
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://research.vu.nl/en/publications/a86f6c56-e080-439d-8239-3d5810cecaaa

BACKGROUND: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. AIM: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. METHODS: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69 years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses. RESULTS: Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14-4.25 cm and 0.18-0.90 cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length. CONCLUSION: Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight.