Genome-wide association study identifies 48 common genetic variants associated with handedness

Verfasser:	Cuellar-Partida, Gabriel Tung, Joyce Y. Eriksson, Nicholas Albrecht, Eva Aliev, Fazil Andreassen, Ole A. Barroso, Inês Beckmann, Jacques S. Boks, Marco P. Boomsma, Dorret I. Boyd, Heather A. Breteler, Monique M.B. Campbell, Harry Chasman, Daniel I. Cherkas, Lynn F. Davies, Gail de Geus, Eco J.C. Deary, Ian J. Deloukas, Panos Dick, Danielle M. Duffy, David L. Eriksson, Johan G. Esko, Tõnu Feenstra, Bjarke Geller, Frank Gieger, Christian Giegling, Ina Gordon, Scott D. Han, Jiali Hansen, Thomas F. Hartmann, Annette M. Hayward, Caroline Heikkilä, Kauko Hicks, Andrew A. Hirschhorn, Joel N. Hottenga, Jouke Jan Huffman, Jennifer E. Hwang, Liang Dar Ikram, M. Arfan Kaprio, Jaakko Kemp, John P. Khaw, Kay Tee Klopp, Norman Konte, Bettina Kutalik, Zoltan Lahti, Jari Li, Xin Loos, Ruth J.F. Luciano, Michelle Magnusson, Sigurdur H. Mangino, Massimo Marques-Vidal, Pedro Martin, Nicholas G. McArdle, Wendy L. McCarthy, Mark I. Medina-Gomez, Carolina Melbye, Mads Melville, Scott A. Metspalu, Andres Milani, Lili Mooser, Vincent Nelis, Mari Nyholt, Dale R. O’Connell, Kevin S. Ophoff, Roel A. Palmer, Cameron Palotie, Aarno Palviainen, Teemu Pare, Guillaume Paternoster, Lavinia Peltonen, Leena Penninx, Brenda W.J.H. Polasek, Ozren Pramstaller, Peter P. Prokopenko, Inga Raikkonen, Katri Ripatti, Samuli Rivadeneira, Fernando Rudan, Igor Rujescu, Dan Smit, Johannes H. Smith, George Davey Smoller, Jordan W. Soranzo, Nicole Spector, Tim D. Pourcain, Beate St Starr, John M. Stefánsson, Hreinn Steinberg, Stacy Teder-Laving, Maris Thorleifsson, Gudmar Stefánsson, Kári Timpson, Nicholas J. Uitterlinden, André G. van Duijn, Cornelia M. van Rooij, Frank J.A. Vink, Jaqueline M. Vollenweider, Peter Vuoksimaa, Eero Waeber, Gérard Wareham, Nicholas J. Warrington, Nicole Waterworth, Dawn Werge, Thomas Wichmann, H. Erich Widen, Elisabeth Willemsen, Gonneke Wright, Alan F. Wright, Margaret J. Xu, Mousheng Zhao, Jing Hua Kraft, Peter Hinds, David A. Lindgren, Cecilia M. Mägi, Reedik Neale, Benjamin M. Evans, David M. Medland, Sarah E.
Dokumenttyp:	Artikel
Erscheinungsdatum:	2021
Reihe/Periodikum:	Cuellar-Partida , G , Tung , J Y , Eriksson , N , Albrecht , E , Aliev , F , Andreassen , O A , Barroso , I , Beckmann , J S , Boks , M P , Boomsma , D I , Boyd , H A , Breteler , M M B , Campbell , H , Chasman , D I , Cherkas , L F , Davies , G , de Geus , E J C , Deary , I J , Deloukas , P , Dick , D M , Duffy , D L , Eriksson , J G , Esko , T , Feenstra , B , Geller , F , Gieger , C , Giegling , I , Gordon , S D , Han , J , Hansen , T F , Hartmann , A M , Hayward , C , Heikkilä , K , Hicks , A A , Hirschhorn , J N , Hottenga , J J , Huffman , J E , Hwang , L D , Ikram , M A , Kaprio , J , Kemp , J P , Khaw , K T , Klopp , N , Konte , B , Kutalik , Z , Lahti , J , Li , X , Loos , R J F , Luciano , M , Magnusson , S H , Mangino , M , Marques-Vidal , P , Martin , N G , McArdle , W L , McCarthy , M I , Medina-Gomez , C , Melbye , M , Melville , S A , Metspalu , A , Milani , L , Mooser , V , Nelis , M , Nyholt , D R , O’Connell , K S , Ophoff , R A , Palmer , C , Palotie , A , Palviainen , T , Pare , G , Paternoster , L , Peltonen , L , Penninx , B W J H , Polasek , O , Pramstaller , P P , Prokopenko , I , Raikkonen , K , Ripatti , S , Rivadeneira , F , Rudan , I , Rujescu , D , Smit , J H , Smith , G D , Smoller , J W , Soranzo , N , Spector , T D , Pourcain , B S , Starr , J M , Stefánsson , H , Steinberg , S , Teder-Laving , M , Thorleifsson , G , Stefánsson , K , Timpson , N J , Uitterlinden , A G , van Duijn , C M , van Rooij , F J A , Vink , J M , Vollenweider , P , Vuoksimaa , E , Waeber , G , Wareham , N J , Warrington , N , Waterworth , D , Werge , T , Wichmann , H E , Widen , E , Willemsen , G , Wright , A F , Wright , M J , Xu , M , Zhao , J H , Kraft , P , Hinds , D A , Lindgren , C M , Mägi , R , Neale , B M , Evans , D M & Medland , S E 2021 , ' Genome-wide association study identifies 48 common genetic variants associated with handedness ' , Nature Human Behaviour , vol. 5 , no. 1 , pp. 59-70 . https://doi.org/10.1038/s41562-020-00956-y
Schlagwörter:	/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR)
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-29212215
Datenquelle:	BASE; Originalkatalog
Powered By:	BASE
Link(s) :	https://research.vu.nl/en/publications/95b31553-ecd4-436f-b633-4d3d2e2a9878

Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10 −8 ) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (r G = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.