Protease inhibitor (Pi) locus, fertility and twinning

In a sample of 160 Dutch twin pairs and their parents, we found that mothers of dizygotic twins had frequencies of the S and Z alleles at the protease inhibitor (Pi) locus that were 3 times higher than a control sample. Mothers of identical twins also had a higher frequency of S than controls. The S allele may thus both increase ovulation rate and enhance the success of multiple pregnancies. There was also an increased frequency of the S allele in fathers of dizygotic twins; however, this may be a secondary effect of assortative mating for family size (indicating by the number of siblings of t... Mehr ...

Verfasser: Boomsma, D.I.
Frants, R.R.
Bank, R.A.
Martin, N.G.
Dokumenttyp: Artikel
Erscheinungsdatum: 1992
Reihe/Periodikum: Boomsma , D I , Frants , R R , Bank , R A & Martin , N G 1992 , ' Protease inhibitor (Pi) locus, fertility and twinning ' , Human Genetics , vol. 89 , no. 3 , pp. 329-332 . https://doi.org/10.1007/BF00220552
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29212182
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vu.nl/en/publications/90edae9c-b2fe-43b6-a4ea-b2dc5edf0ce7

In a sample of 160 Dutch twin pairs and their parents, we found that mothers of dizygotic twins had frequencies of the S and Z alleles at the protease inhibitor (Pi) locus that were 3 times higher than a control sample. Mothers of identical twins also had a higher frequency of S than controls. The S allele may thus both increase ovulation rate and enhance the success of multiple pregnancies. There was also an increased frequency of the S allele in fathers of dizygotic twins; however, this may be a secondary effect of assortative mating for family size (indicating by the number of siblings of the parents), for which a correlation of 0.2 was observed. Parents of dizygotic twins came from larger families than parents of monozygotic twins, but no effect of Pi type on family size was seen. © 1992 Springer-Verlag.