Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First Phase Glucose Stimulated Insulin Secretion During Hyperglycemic Clamps

OBJECTIVE - At least 20 type 2 diabetes loci have now been identified, and several of these are associated with altered β-cell function. In this study, we have investigated the combined effects of eight known β-cell loci on insulin secretion stimulated by three different secretagogues during hyperglycemic clamps. RESEARCH DESIGN AND METHODS - A total of 447 subjects originating from four independent studies in the Netherlands and Germany (256 with normal glucose tolerance [NGT]/ 191 with impaired glucose tolerance [IGT]) underwent a hyperglycemic clamp. A subset had an extended clamp with addi... Mehr ...

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Verfasser: Hart, L.M.
Bik-Simonis, A.M.C.
Nijpels, G.
van Haeften, T.W.
Schäfer, S.A.
Houwing-Duistermaat, J.J.
Boomsma, D.I.
Groenewoud, M.J.
Reiling, E.
van Hove, E.C.
Diamant, M.
Kramer, M.H.H.
Heine, R.J.
Maassen, J.A.
Kirchhoff, K.
Machicao, F.
Häring, H.U.
Slagboom, P.E.
Willemsen, G.
Eekhoff, E.M.W.
de Geus, E.J.C.
Dekker, J.J.M.
Fritsche, A.
Dokumenttyp: Artikel
Erscheinungsdatum: 2010
Reihe/Periodikum: Hart , L M , Bik-Simonis , A M C , Nijpels , G , van Haeften , T W , Schäfer , S A , Houwing-Duistermaat , J J , Boomsma , D I , Groenewoud , M J , Reiling , E , van Hove , E C , Diamant , M , Kramer , M H H , Heine , R J , Maassen , J A , Kirchhoff , K , Machicao , F , Häring , H U , Slagboom , P E , Willemsen , G , Eekhoff , E M W , de Geus , E J C , Dekker , J J M & Fritsche , A 2010 , ' Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First Phase Glucose Stimulated Insulin Secretion During Hyperglycemic Clamps ' , Diabetes , vol. 59 , no. 1 , pp. 287-292 . https://doi.org/10.2337/db09-0736
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29211958
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://research.vu.nl/en/publications/8296cfb4-d670-4ca8-a328-1dcdcd8b7fb3

OBJECTIVE - At least 20 type 2 diabetes loci have now been identified, and several of these are associated with altered β-cell function. In this study, we have investigated the combined effects of eight known β-cell loci on insulin secretion stimulated by three different secretagogues during hyperglycemic clamps. RESEARCH DESIGN AND METHODS - A total of 447 subjects originating from four independent studies in the Netherlands and Germany (256 with normal glucose tolerance [NGT]/ 191 with impaired glucose tolerance [IGT]) underwent a hyperglycemic clamp. A subset had an extended clamp with additional glucagon-like peptide (GLP)-1 and arginine (n = 224). We next genotyped single nucleotide polymorphisms in TCF7L2, KCNJ11, CDKAL1, IGF2BP2, HHEX/IDE, CDKN2A/B, SLC30A8, and MTNR1B and calculated a risk allele score by risk allele counting. RESULTS - The risk allele score was associated with lower first-phase glucose-stimulated insulin secretion (GSIS) (P = 7.1 × 10