Sex differences in the human peripheral blood transcriptome

Background: Genomes of men and women differ in only a limited number of genes located on the sex chromosomes, whereas the transcriptome is far more sex-specific. Identification of sex-biased gene expression will contribute to understanding the molecular basis of sex-differences in complex traits and common diseases.Results: Sex differences in the human peripheral blood transcriptome were characterized using microarrays in 5,241 subjects, accounting for menopause status and hormonal contraceptive use. Sex-specific expression was observed for 582 autosomal genes, of which 57.7% was upregulated i... Mehr ...

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Verfasser: Jansen, R.
Batista, S.
Brooks, A.I.
Tischfield, J.A.
Willemsen, G.
Grootheest, G.
Hottenga, J.J.
Milaneschi, Y.
Mbarek, H.
Madar, V.
Peyrot, W.
Vink, J.M.
Verweij, C.L.
de Geus, E.J.C.
Smit, J.H.
Wright, F.A.
Sullivan, P.F.
Boomsma, D.I.
Penninx, B.W.J.H.
Dokumenttyp: Artikel
Erscheinungsdatum: 2014
Reihe/Periodikum: Jansen , R , Batista , S , Brooks , A I , Tischfield , J A , Willemsen , G , Grootheest , G , Hottenga , J J , Milaneschi , Y , Mbarek , H , Madar , V , Peyrot , W , Vink , J M , Verweij , C L , de Geus , E J C , Smit , J H , Wright , F A , Sullivan , P F , Boomsma , D I & Penninx , B W J H 2014 , ' Sex differences in the human peripheral blood transcriptome ' , BMC Genomics , vol. 15 , 33 , pp. 33 . https://doi.org/10.1186/1471-2164-15-33
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29211837
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://research.vu.nl/en/publications/755b8391-e837-4ed9-a35e-3b4bf15e7c8f

Background: Genomes of men and women differ in only a limited number of genes located on the sex chromosomes, whereas the transcriptome is far more sex-specific. Identification of sex-biased gene expression will contribute to understanding the molecular basis of sex-differences in complex traits and common diseases.Results: Sex differences in the human peripheral blood transcriptome were characterized using microarrays in 5,241 subjects, accounting for menopause status and hormonal contraceptive use. Sex-specific expression was observed for 582 autosomal genes, of which 57.7% was upregulated in women (female-biased genes). Female-biased genes were enriched for several immune system GO categories, genes linked to rheumatoid arthritis (16%) and genes regulated by estrogen (18%). Male-biased genes were enriched for genes linked to renal cancer (9%). Sex-differences in gene expression were smaller in postmenopausal women, larger in women using hormonal contraceptives and not caused by sex-specific eQTLs, confirming the role of estrogen in regulating sex-biased genes.Conclusions: This study indicates that sex-bias in gene expression is extensive and may underlie sex-differences in the prevalence of common diseases. © 2014 Jansen et al.; licensee BioMed Central Ltd.