Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment in patients with BD. Weighted polygenic scores (PGSs) were computed for major depression (MD) at different GWAS p value thresholds using genetic data obtained from 2586 bipolar patients who received lithium treatment and took part in the Consortium on Lith... Mehr ...

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Verfasser: Amare, Azmeraw T
Baune, Bernhard T
Abdellaoui, A.
Dolan, C.V.
Hottenga, Jouke Jan
Mbarek, Hamdi
Middeldorp, C.M.
Nivard, Michel G.
Willemsen, Gonneke
Boomsma, D.I.
de Geus, Eco J.C.
Beekman, Aartjan F T
Jansen, Rick
Milaneschi, Yuri
Peyrot, Wouter J
Smit, Johannes H.
W J H Penninx, Brenda
Posthuma, Danielle
Dokumenttyp: Artikel
Erscheinungsdatum: 2021
Reihe/Periodikum: Amare , A T , Baune , B T , Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium , Abdellaoui , A , Dolan , C V , Hottenga , J J , Mbarek , H , Middeldorp , C M , Nivard , M G , Willemsen , G , Boomsma , D I , de Geus , E J C , Beekman , A F T , Jansen , R , Milaneschi , Y , Peyrot , W J , Smit , J H , W J H Penninx , B & Posthuma , D 2021 , ' Association of polygenic score for major depression with response to lithium in patients with bipolar disorder ' , Molecular Psychiatry , vol. 26 , no. 6 , pp. 2457-2470 . https://doi.org/10.1038/s41380-020-0689-5
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR) / /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being / name=SDG 3 - Good Health and Well-being
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29211723
Datenquelle: BASE; Originalkatalog
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Link(s) : https://research.vu.nl/en/publications/665fd2ba-cb01-470c-9200-3b5fdaf53d80