Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education

Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allo... Mehr ...

Verfasser: Jelenkovic, Aline
Sund, Reijo
Yokoyama, Yoshie
Latvala, Antti
Sugawara, Masumi
Tanaka, Mami
Matsumoto, Satoko
Freitas, Duarte L
Maia, José Antonio
Knafo-Noam, Ariel
Mankuta, David
Abramson, Lior
Ji, Fuling
Ning, Feng
Pang, Zengchang
Rebato, Esther
Saudino, Kimberly J
Cutler, Tessa L
Hopper, John L
Ullemar, Vilhelmina
Almqvist, Catarina
Magnusson, Patrik K E
Cozen, Wendy
Hwang, Amie E
Mack, Thomas M
Nelson, Tracy L
Whitfield, Keith E
Sung, Joohon
Kim, Jina
Lee, Jooyeon
Lee, Sooji
Llewellyn, Clare H
Fisher, Abigail
Medda, Emanuela
Nisticò, Lorenza
Toccaceli, Virgilia
Baker, Laura A
Tuvblad, Catherine
Corley, Robin P
Huibregtse, Brooke M
Derom, Catherine A
Vlietinck, Robert F
Loos, Ruth J F
Burt, S Alexandra
Klump, Kelly L
Silberg, Judy L
Maes, Hermine H
Krueger, Robert F
McGue, Matt
Pahlen, Shandell
Gatz, Margaret
Butler, David A
Harris, Jennifer R
Brandt, Ingunn
Nilsen, Thomas S
Harden, K Paige
Tucker-Drob, Elliot M
Franz, Carol E
Kremen, William S
Lyons, Michael J
Lichtenstein, Paul
Bartels, Meike
Beijsterveldt, Catharina E M van
Willemsen, Gonneke
Öncel, Sevgi Y
Aliev, Fazil
Jeong, Hoe-Uk
Hur, Yoon-Mi
Turkheimer, Eric
Boomsma, Dorret I
Sørensen, Thorkild I A
Kaprio, Jaakko
Silventoinen, Karri
Dokumenttyp: Artikel
Erscheinungsdatum: 2020
Reihe/Periodikum: Jelenkovic , A , Sund , R , Yokoyama , Y , Latvala , A , Sugawara , M , Tanaka , M , Matsumoto , S , Freitas , D L , Maia , J A , Knafo-Noam , A , Mankuta , D , Abramson , L , Ji , F , Ning , F , Pang , Z , Rebato , E , Saudino , K J , Cutler , T L , Hopper , J L , Ullemar , V , Almqvist , C , Magnusson , P K E , Cozen , W , Hwang , A E , Mack , T M , Nelson , T L , Whitfield , K E , Sung , J , Kim , J , Lee , J , Lee , S , Llewellyn , C H , Fisher , A , Medda , E , Nisticò , L , Toccaceli , V , Baker , L A , Tuvblad , C , Corley , R P , Huibregtse , B M , Derom , C A , Vlietinck , R F , Loos , R J F , Burt , S A , Klump , K L , Silberg , J L , Maes , H H , Krueger , R F , McGue , M , Pahlen , S , Gatz , M , Butler , D A , Harris , J R , Brandt , I , Nilsen , T S , Harden , K P , Tucker-Drob , E M , Franz , C E , Kremen , W S , Lyons , M J , Lichtenstein , P , Bartels , M , Beijsterveldt , C E M V , Willemsen , G , Öncel , S Y , Aliev , F , Jeong , H-U , Hur , Y-M , Turkheimer , E , Boomsma , D I , Sørensen , T I A , Kaprio , J & Silventoinen , K 2020 , ' Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education ' , Scientific Reports , vol. 10 , no. 1 , 7974 , pp. 7974 . https://doi.org/10.1038/s41598-020-64883-8
Schlagwörter: /dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_ / name=Netherlands Twin Register (NTR)
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29211309
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://research.vu.nl/en/publications/372dce3d-6342-46d3-819e-989e78bfb1b3

Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at different ages and in three geographic-cultural regions (Europe, North America and Australia, and East Asia). Parental education mostly showed a positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. In variance decomposition modeling, the genetic and environmental variance components of height did not show a consistent relation to parental education. A random-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shared environmental variation of height in low parental education families. In conclusion, in our very large dataset from twin cohorts around the globe, these results provide only weak evidence for the study hypothesis.