European experience with the Afirma Gene Expression Classifier for indeterminate thyroid nodules:A clinical utility study in the Netherlands
Background: The Gene Expression Classifier (GEC) and Genomic Sequencing Classifier (GSC) were developed to improve risk stratification of indeterminate nodules. Our aim was to assess the clinical utility in a European population with restrictive diagnostic workup. Methods: Clinical utility of the GEC was assessed in a prospective multicenter cohort of 68 indeterminate nodules. Diagnostic surgical rates for Bethesda III and IV nodules were compared to a historical cohort of 171 indeterminate nodules. Samples were post hoc tested with the GSC. Results: The GEC classified 26% as benign. Surgical... Mehr ...
Verfasser: |
Lončar, Ivona
van Velsen, Evert F.S.
Massolt, Elske T.
van Kemenade, Folkert J.
van Engen-van Grunsven, Adriana C.H.
van Hemel, Bettien M.
van Nederveen, Francien H.
Netea-Maier, Romana
Links, Thera P.
Peeters, Robin P.
van Ginhoven, Tessa M. |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2023 |
Reihe/Periodikum: |
Lončar , I , van Velsen , E F S , Massolt , E T , van Kemenade , F J , van Engen-van Grunsven , A C H , van Hemel , B M , van Nederveen , F H , Netea-Maier , R , Links , T P , Peeters , R P & van Ginhoven , T M 2023 , ' European experience with the Afirma Gene Expression Classifier for indeterminate thyroid nodules : A clinical utility study in the Netherlands ' , Head and Neck , vol. 45 , no. 9 , pp. 2227-2236 . https://doi.org/10.1002/hed.27472 |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-29209004 |
Datenquelle: |
BASE;
Originalkatalog |
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Link(s) :
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https://pure.eur.nl/en/publications/7a49efd4-57ae-4bb3-a1bd-30c5fc0e1ff0 |