Early-Life Risk Factors for Carotid Intima-Media Thickness and Carotid Stiffness in Adolescence

IMPORTANCE: Atherogenesis starts during childhood, making childhood and adolescence an important window of opportunity to prevent atherosclerotic cardiovascular disease later in life. OBJECTIVE: To identify early-life risk factors for preclinical atherosclerosis in adolescence. DESIGN, SETTING, AND PARTICIPANTS: This cohort study is part of the ongoing Wheezing Illness Study in Leidsche Rijn (WHISTLER) prospective birth cohort study, which includes 3005 healthy newborns born between December 2001 and December 2012 in the Leidsche Rijn area of Utrecht, the Netherlands. Eligible participants inc... Mehr ...