Optimising primary molecular profiling in non-small cell lung cancer

Introduction Molecular profiling of NSCLC is essential for optimising treatment decisions, but often incomplete. We assessed the efficacy of protocolised molecular profiling in the current standard-of-care (SoC) in a prospective observational study in the Netherlands and measured the effect of providing standardised diagnostic procedures. We also explored the potential of plasma-based molecular profiling in the primary diagnostic setting. Methods This multi-centre prospective study was designed to explore the performance of current clinical practice during the run-in phase using local SoC tiss... Mehr ...