Short telomere length is associated with impaired cognitive performance in European ancestry cohorts
The association between telomere length (TL) dynamics on cognitive performance over the life-course is not well understood. This study meta-analyses observational and causal associations between TL and six cognitive traits, with stratifications on APOE genotype, in a Mendelian Randomization (MR) framework. Twelve European cohorts (N = 17 052; mean age = 59.2 ± 8.8 years) provided results for associations between qPCR-measured TL (T/S-ratio scale) and general cognitive function, mini-mental state exam (MMSE), processing speed by digit symbol substitution test (DSST), visuospatial functioning, m... Mehr ...
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| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 2017 |
| Schlagwörter: | apolipoprotein E4 / acyp2 gene / adult / ancestry group / article / cognition / cognitive defect / cohort analysis / depth perception / digit symbol substitution test / episodic memory / executive function / female / gene / genetic association / genetic risk / genetic variability / genome-wide association study / genotype / human / learning / major clinical study / male / Mendelian randomization analysis / Mini Mental State Examination / naf1 gene / Netherlands / obfc1 gene / observational study / pleiotropy / polymerase chain reaction / quantitative analysis / rtel1 gene / single nucleotide polymorphism / Stroop test / telomere length / terc gene / tert gene / znf208 gene |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-29202032 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://dspace.library.uu.nl/handle/1874/362867 |
