Breast Cancer Risk After Radiation Therapy for Hodgkin Lymphoma: Influence of Gonadal Hormone Exposure

BACKGROUND: Young women treated with chest radiation therapy (RT) for Hodgkin lymphoma (HL) experience a strongly increased risk of breast cancer (BC). It is unknown whether endogenous and exogenous gonadal hormones affect RT-associated BC risk. METHODS: We conducted a nested case-control study among female 5-year HL survivors treated before age 41. Hormone exposure and HL treatment data were collected through medical records and questionnaires for 174 BC case patients and 466 control patients. Radiation dose to breast tumor location was estimated based on RT charts, simulation films, and mamm... Mehr ...

Verfasser: Krul, Inge M
Opstal-van Winden, Annemieke W J
Aleman, Berthe M P
Janus, Cécile P M
van Eggermond, Anna M
De Bruin, Marie L
Hauptmann, Michael
Krol, Augustinus D G
Schaapveld, Michael
Broeks, Annegien
Kooijman, Karen R
Fase, Sandra
Lybeert, Marnix L
Zijlstra, Josée M
van der Maazen, Richard W M
Kesminiene, Ausrele
Diallo, Ibrahima
de Vathaire, Florent
Russell, Nicola S
van Leeuwen, Flora E
Dokumenttyp: Artikel
Erscheinungsdatum: 2017
Schlagwörter: Adult / Antineoplastic Agents / Alkylating / Breast / Breast Neoplasms / Carcinoma / Intraductal / Noninfiltrating / Case-Control Studies / Confidence Intervals / Dose-Response Relationship / Radiation / Female / Gonadal Steroid Hormones / Hodgkin Disease / Hormone Replacement Therapy / Humans / Menopause / Premature / Middle Aged / Neoplasms / Radiation-Induced / Netherlands / Ovary / Procarbazine / Radiotherapy Dosage / Risk Factors / Survivors / Time Factors / Young Adult / Journal Article / Taverne
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29202014
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://dspace.library.uu.nl/handle/1874/361848

BACKGROUND: Young women treated with chest radiation therapy (RT) for Hodgkin lymphoma (HL) experience a strongly increased risk of breast cancer (BC). It is unknown whether endogenous and exogenous gonadal hormones affect RT-associated BC risk. METHODS: We conducted a nested case-control study among female 5-year HL survivors treated before age 41. Hormone exposure and HL treatment data were collected through medical records and questionnaires for 174 BC case patients and 466 control patients. Radiation dose to breast tumor location was estimated based on RT charts, simulation films, and mammography reports. RESULTS: We observed a linear radiation dose-response curve with an adjusted excess odds ratio (EOR) of 6.1%/Gy (95% confidence interval [CI]: 2.1%-15.4%). Women with menopause <30 years (caused by high-dose procarbazine or pelvic RT) had a lower BC risk (OR, 0.13; 95% CI, 0.03-0.51) than did women with menopause ≥50 years. BC risk increased by 6.4% per additional year of post-RT intact ovarian function (P<.001). Among women with early menopause (<45 years), hormone replacement therapy (HRT) use for ≥2 years did not increase BC risk (OR, 0.86; 95% CI, 0.32-2.32), whereas this risk was nonsignificantly increased among women without early menopause (OR, 3.69; 95% CI, 0.97-14.0; P for interaction: .06). Stratification by duration of post-RT intact ovarian function or HRT use did not statistically significantly modify the radiation dose-response curve. CONCLUSIONS: BC risk in female HL survivors increases linearly with radiation dose. HRT does not appear to increase BC risk for HL survivors with therapy-induced early menopause. There are no indications that endogenous and exogenous gonadal hormones affect the radiation dose-response relationship.