Genetic Diversity in the Major Capsid L1 Protein of HPV-16 and HPV-18 in the Netherlands
Objectives Intratypic molecular variants of human papillomavirus (HPV) type-16 and -18 exist. In the Netherlands, a bivalent vaccine, composed of recombinant L1 proteins from HPV-16 and -18, is used to prevent cervical cancer since 2009. Long-term vaccination could lead to changes in HPV-16 and -18 virus population, thereby hampering vaccination strategies. We determined the genetic diversity of the L1 gene in HPV-16 and -18 viral strains circulating in the Netherlands at the start of vaccination in order to understand the baseline genetic diversity in the Dutch population. Methods DNA sequenc... Mehr ...
Verfasser: | |
---|---|
Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2016 |
Schlagwörter: | General Medicine / General Biochemistry / Genetics and Molecular Biology / General Agricultural and Biological Sciences / Journal Article / Research Support / Non-U.S. Gov't |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-29201715 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | https://dspace.library.uu.nl/handle/1874/343927 |