Mutations in the hemochromatosis gene (HFE) and stroke

BACKGROUND AND PURPOSE: Increased serum iron is found to be a risk factor for stroke. Carriers of HFE C282Y and H63D mutations have elevated serum iron levels and may have an increased risk for stroke. We studied the association between HFE gene mutations, carotid atherosclerosis, and stroke. METHODS: We compared the frequency of the HFE C282Y and H63D gene mutations in 202 prevalent and incident cases of strok

Verfasser: Njajou, O.T. (Omer)
Hollander, M. (Monika)
Koudstaal, P.J. (Peter)
Hofman, A. (Albert)
Duijn, C.M. (Cornelia) van
Witteman, J.C.M. (Jacqueline)
Breteler, M.M.B. (Monique)
Dokumenttyp: Artikel
Erscheinungsdatum: 2002
Schlagwörter: *Mutation / 0 (HFE protein / human) / 0 (Histocompatibility Antigens Class I) / 0 (Membrane Proteins) / Aged / Blood Pressure / Carotid Arteries/ultrasonography / Carotid Artery Diseases/epidemiology/ultrasonography / Cerebrovascular Accident/epidemiology/*genetics / Cohort Studies / Comorbidity / Female / Hemochromatosis/epidemiology/*genetics / Heterozygote Detection / Histocompatibility Antigens Class I/*genetics / Human / Hypertension/epidemiology / Logistic Models / Male / Membrane Proteins/*genetics / Middle Aged / Netherlands/epidemiology / Odds Ratio / Smoking/epidemiology / Support / Non-U.S. Gov't / Tunica Intima/ultrasonography / Tunica Media/ultrasonography / atherosclerosis / stroke
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29199373
Datenquelle: BASE; Originalkatalog
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Link(s) : http://repub.eur.nl/pub/5982