Genome-wide linkage analysis in a Dutch multigenerational family with attention deficit hyperactivity disorder
Abstract: Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder. Genetics has an important role in the aetiology of this disease. In this study, we describe the clinical findings in a Dutch family with eight patients suffering from ADHD, in whom five had at least one other psychiatric disorder. We performed a genome-wide (parametric and nonparametric) affected-only linkage analysis. Two genomic regions on chromosomes 7 and 14 showed an excess of allele sharing among the definitely affected members of the family with suggestive LOD scores (2.1 and 2.08). Nonparam... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2010 |
Schlagwörter: | *Chromosomes / Human / Pair 14 / Pair 7 / Attention Deficit Disorder with Hyperactivity/*genetics / Chromosome Aberrations / Chromosome Mapping / Comorbidity / Female / Genetic Markers / Genome-Wide Association Study/*methods / Haplotypes/genetics / Humans / Male / Microsatellite Repeats/genetics / Netherlands / Pedigree |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-29199108 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://repub.eur.nl/pub/23079 |