Angiotensin converting enzyme gene polymorphism and cardiovascular morbidity and mortality: the Rotterdam Study.

BACKGROUND: Findings on the association between the insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene and cardiovascular morbidity and mortality have been inconsistent. Considering the possible interaction between this polymorphism and smoking, we evaluated the association between ACE I/D polymorphism and myocardial infarction (MI), mortality due to coronary heart disease (CHD), and cardiovascular disease (CVD). METHODS: The study was performed within the Rotterdam Study, a population based cohort study. The ACE I/D polymorphism was determined for 6714 par... Mehr ...

Verfasser: Sayed-Tabatabaei, F.A. (Fakhredin)
Schut, A.F.C. (Anna)
Arias-Vásquez, A. (Alejandro)
Bertoli Avella, A.M. (Aida)
Hofman, A. (Albert)
Witteman, J.C.M. (Jacqueline)
Duijn, C.M. (Cornelia) van
Dokumenttyp: Artikel
Erscheinungsdatum: 2005
Schlagwörter: *Polymorphism / Genetic / Aged / 80 and over / Cardiovascular Diseases/*epidemiology/*genetics/mortality / Cohort Studies / Follow-Up Studies / Genotype / Humans / Introns / Middle Aged / Morbidity / Myocardial Infarction/epidemiology/genetics/mortality / Netherlands/epidemiology / Peptidyl-Dipeptidase A/*genetics / Risk Factors / Smoking/epidemiology / Time Factors
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29198923
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : http://repub.eur.nl/pub/13629

BACKGROUND: Findings on the association between the insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene and cardiovascular morbidity and mortality have been inconsistent. Considering the possible interaction between this polymorphism and smoking, we evaluated the association between ACE I/D polymorphism and myocardial infarction (MI), mortality due to coronary heart disease (CHD), and cardiovascular disease (CVD). METHODS: The study was performed within the Rotterdam Study, a population based cohort study. The ACE I/D polymorphism was determined for 6714 participants and smoking status recorded at baseline. Fatal and non-fatal MIs and mortality events were regularly recorded. Cox proportional hazard analysis was performed separately for current smokers and non-smokers. We used age as the follow up time, presenting age specific survivals. RESULTS: During follow up, 248 MIs and 301 and 482 deaths, respectively, du