Molecular epidemiology of pneumococcal colonization in response to pneumococcal conjugate vaccination in children with recurrent acute otitis media.
A randomized double-blind trial with a 7-valent pneumococcal conjugate vaccine was conducted in The Netherlands among 383 children, aged 1 to 7 years, with a history of recurrent acute otitis media. No effect of vaccination on the pneumococcal colonization rate was found. However, a shift in serotype distribution was clearly observed (R. Veenhoven et al., Lancet 361:2189-2195, 2003). We investigated the molecular epidemiology of 921 pneumococcal isolates retrieved from both the pneumococcal vaccine (PV) and control vaccine (CV) groups during the vaccination study. Within individuals a high tur... Mehr ...
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Dokumenttyp: | Artikel |
Erscheinungsdatum: | 2005 |
Schlagwörter: | Acute Disease / Child / Preschool / Double-Blind Method / Epidemiology / Molecular / Humans / Infant / Nasopharynx/*microbiology / Netherlands/epidemiology / Otitis Media/epidemiology/*microbiology/prevention & control / Pneumococcal Infections/microbiology/prevention & control / Pneumococcal Vaccines/*administration & dosage/therapeutic use / Recurrence / Streptococcus pneumoniae/classification/*genetics/*growth & development/isolation & purification / Vaccination / Vaccines / Conjugate/*administration & dosage/therapeutic use |
Sprache: | Englisch |
Permalink: | https://search.fid-benelux.de/Record/base-29198922 |
Datenquelle: | BASE; Originalkatalog |
Powered By: | BASE |
Link(s) : | http://repub.eur.nl/pub/13628 |