Trends in treatment and survival of gallbladder cancer in the Netherlands; Identifying gaps and opportunities from a nation-wide cohort

Gallbladder cancer (GBC) is rare in Western populations and data about treatment and outcomes are scarce. This study aims to analyze survival and identify opportunities for improvement using population-based data from a low-incidence country. GBC patients diagnosed between 2005 and 2016 with GBC were identified from the Netherlands Cancer Registry. Patients were grouped according to time period (2005-2009/2010-2016) and disease stage. Trends in treatment and overall survival (OS) were analyzed. In total 1834 patients were included: 661 (36%) patients with resected, 278 (15%) with non-resected... Mehr ...

Verfasser: de Savornin Lohman, E. (Elise)
de Bitter, T. (Tessa)
Verhoeven, R.H.A. (Rob)
van der Geest, L.G.M. (Lydia G.M.)
Hagendoorn, J. (Jeroen)
Mohammad, N.H. (Nadia Haj)
Daams, F. (Freek)
Heinz-Josef Klümpen, ()
Gulik, T.M. (Thomas) van
Erdmann, J.I. (Joris)
Boer, M.T. (Marieke) de
Hoogwater, F. (Frederik)
Koerkamp, B.G. (Bas Groot)
Braat, A.E. (Andries)
Verheij, J. (Joanne)
Nagtegaal, I.D. (Iris)
Laarhoven, C.J. (Cees) van
Boezem, P.B. van den
Van Der Post, R.S. (Rachel S.)
Reuver, P.R. (Philip) de
Dokumenttyp: Artikel
Erscheinungsdatum: 2020
Schlagwörter: Chemotherapy / Cohort studies / Epidemiology / Gallbladder neoplasms / Surgery
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29198794
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : http://repub.eur.nl/pub/126531

Gallbladder cancer (GBC) is rare in Western populations and data about treatment and outcomes are scarce. This study aims to analyze survival and identify opportunities for improvement using population-based data from a low-incidence country. GBC patients diagnosed between 2005 and 2016 with GBC were identified from the Netherlands Cancer Registry. Patients were grouped according to time period (2005-2009/2010-2016) and disease stage. Trends in treatment and overall survival (OS) were analyzed. In total 1834 patients were included: 661 (36%) patients with resected, 278 (15%) with non-resected non-metastatic, and 895 (49%) with metastatic GBC. Use of radical versus simple cholecystectomy (12% vs. 26%, p < 0.001) in early (pT1b/T2) GBC increased. More patients with metastatic GBC received chemotherapy (11% vs. 29%, p < 0.001). OS improved from 4.8 months (2005-2009) to 6.1 months (2010-2016) (p = 0.012). Median OS increased over time (2005-2009 vs. 2010-2016) in resected (19.4 to 26.8 months, p = 0.038) and metastatic (2.3 vs. 3.4 months, p = 0.001) GBC but not in unresected, non-metastatic GBC. In early GBC, patients with radical cholecystectomy had a median OS of 76.7 compared to 18.4 months for simple cholecystectomy (p < 0.001). Palliative chemotherapy showed superior (p < 0.001) survival in metastat