Dermatofibrosarcoma protuberans re-excision and recurrence rates in the netherlands between 1989 and 2016

Dermatofibrosarcoma protuberans is a rare soft tissue tumour with a very low (< 0.5%) rate of metastasis. Rates of re-excision and recurrence were determined using data from the Netherlands Cancer Registry between 1989 and 2016. Of the 1,890 instances of dermatofibrosarcoma protuberans included, 87% were treated with excision, 4% with Mohs micrographic surgery, and 9% otherwise or unknown. Linked pathology data were retrieved for 1,677 patients. Half of all excisions (847/1,644) were incomplete and 29% (192/622) of all re-excisions were incomplete. The cumulative incidence of a recurrence w... Mehr ...

Verfasser: Lee, C.B. (Charlotte) van
Kan, W.C. (Wilner C.)
Gran, S. (Sonia)
Mooyaart, A.L. (Antien)
Mureau, M.A.M. (Marc)
Williams, H.
Matin, R. (Rubeta)
Bos, R.R. (Renate) van den
Hollestein, L.M. (Loes)
Dokumenttyp: Artikel
Erscheinungsdatum: 2019
Schlagwörter: Dermatofibrosarcoma protuberans / Histological clearance / Mohs micrographic surgery / Recurrence / Surgical excision
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29198630
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : http://repub.eur.nl/pub/120952

Dermatofibrosarcoma protuberans is a rare soft tissue tumour with a very low (< 0.5%) rate of metastasis. Rates of re-excision and recurrence were determined using data from the Netherlands Cancer Registry between 1989 and 2016. Of the 1,890 instances of dermatofibrosarcoma protuberans included, 87% were treated with excision, 4% with Mohs micrographic surgery, and 9% otherwise or unknown. Linked pathology data were retrieved for 1,677 patients. Half of all excisions (847/1,644) were incomplete and 29% (192/622) of all re-excisions were incomplete. The cumulative incidence of a recurrence was 7% (95% confidence interval (CI) 6–8) during a median followup of 11 years (interquartile range (IQR) 6–17). After Mohs micrographic surgery (n = 34), there were no recurrences during a median follow-up of 4 years (IQR 3–6). Due to the high rate of incomplete excisions and recurrences after excision, this study supports the European guideline, which recommends treating dermatofibrosarcoma protuberans with Mohs micrographic surgery in order to decrease the rate of recurrence.