High treatment uptake in human immunodeficiency virus/ hepatitis C virus-coinfected patients after unrestricted access to direct-acting antivirals in the Netherlands

Verfasser:	Boerekamps, A. (Anne) Newsum, A.M. (Astrid M.) Smit, C. (Colette) Arends, J.E. (Joop) Richter, C. (Clemens) Reiss, P. (Peter) Rijnders, B.J.A. (Bart) Brinkman, K. (Kees) Valk, M. (Marc) van der Geerlings, S.E. (Suzanne) Godfried, M.H. Goorhuis, A. (Abraham) Hovius, J.W.R. (Joppe) Meer, J.T.M. (J. T M) van der Kuijpers, T.W. (Taco W.) Nellen, F.J.B. (F. J B) Van Der Poll, D.T. (D. T.) Prins, J.M. (Jan) Van Vugt, H.J.M. (H. J.M.) Wiersinga, W.J. (W. J.) Wit, F.W.N.M. (Ferdinand) Van Duinen, M. (M.) Van Eden, J. Van Hes, A.M.H. Mutschelknauss, M. Nobel, H.E. Pijnappel, F.J.J. Weijsenfeld, A.M. Jurriaans, S. (Suzanne) Back, N. (Nicole) Zaaijer, H.L. (Hans) Berkhout, B. (Ben) Cornelissen, M. (Marion) Schinkel, C.J. Wolthers, K.C. (Katja) Van Den Berge, M. Stegeman, A. Baas, S. Hage De Looff, L. (L.) Wintermans, B. (B.) Veenemans, J. (J.) Pronk, M.J.H. (Marjolijn) Ammerlaan, H.S.M. (Heidi) De Munnik, E.S. Jansz, A.R. (A. R.) Tjhie, J. (J.) Wegdam, M.C.A. Deiman, B. (B.) Scharnhorst, V. Eeden, A. (Arne) van Brokking, W. (W.) Groot, M.M. (Marieke) Elsenburg, L.J.M. (L. J.M.) Damen, M. (M.) Kwa, I.S. Kasteren, M.E.E. (Marjo) van Brouwer, A.E. Van Erve, R. (R.) De Kruijf-Van De Wiel, B.A.F.M. (B. A.F.M.) Keelan-Pfaf, S. (S.) Van Der Ven, B. (B.) Van Der Ven, B. Buiting, A.G.M. (Anton) Kabel, P.J. (P. J.) Versteeg, D. Ende, M.E. (Marchina) van der Bax, H.I. (Hannelore) Gorp, E.C.M. (Eric) van Nouwen, J.L. (Jan) Schurink, C.A.M. (Carolina) Verbon, A. (Annelies) Vriessluijs, T.E.M.S. (Theodora) de De Jong-Peltenburg, N.C. (N. C.) Bassant, N. Van Beek, J.E.A. Vriesde, M. van Zonneveld, L. (Laura) Van Den Berg-Cameron, H.J. Groot, J.C. (Jan Cees) de De Zeeuw-De Man, M. Boucher, C.A.B. (Charles) Koopmans D.V.M., M.P.G. (Marion) Kampen, J.J.A. (Jeroen) van Pas, S.D. (Suzan) Branger, J. Rijkeboer-Mes, A. (A.) Duijf-Van De Ven, C.J.H.M. Schippers, E.F. (E. F.) Nieuwkoop, C. (Cees) van Van IJperen, J.M. (J. M.) Geilings, J. (J.) Van Der Hut, G. Burgel, N.D. (Nathalie ) van Leyten, E.M.S. (Eliane) Gelinck, L.B.S. (Luc) Van Hartingsveld, A.Y. (A. Y.) Meerkerk, C. Wildenbeest, G.S. Heikens, E. (E.) Groeneveld, P.H.P. (P. H.P.) Bouwhuis, J.W. (Jolande) Lammers, A.J.J. (A. J.J.) Kraan, S. (S.) Van Hulzen, A.G.W. Van Der Bliek, G.L. (G. L.) Bor, P.C.J. Bloembergen, P. (Peter) Wolfhagen, M.J.H.M. Ruijs, G. (G.) Kroon, F.P. (F. P.) Boer, M.G.J. (Mark) de Scheper, H. (H.) Jolink, A. (Albert) Vollaard, A. (Albert) Dorama, W. (Willemien) Van Holten, N. (N.) Claas, E.C.J. (Eric) Wessels, E. (E.) Hollander, J.G. (Jan) den Pogány, K. (Katalin) Roukens, A. (A.) Kastelijns, M. (M.) Smit, J.V. Smit, E. Struik-Kalkman, D. (D.) Tearno, C. (C.) Van Niekerk, T. Pontesilli, O. (Oscar) Lowe, S.H. (S. H.) Oude Lashof, A. (A.) Posthouwer, D. (Dirk) Ackens, R.P. (R. P.) Burgers, K. (K.) Schippers, J. Weijenberg-Maes, B. (B.) Loo, I. (Inge) van Havenith, T. Mulder, J.W. (J. W.) Vrouenraets, B.C. (Bart) Lauw, F.N. (F. N.) van Broekhuizen, M. (Marjolein) Vlasblom, D.J. Smits, P.H.M. (Paul) Weijer, S. (S.) El Moussaoui, R. Bosma, A.S. (A. S.) Vonderen, M.G.A. van Van Houte, D.P.F. Kampschreur, L.M. Dijkstra, K. (K.) Faber, S. Weel, J. (J.) Kootstra, J.G. (Jille) Delsing, C.E. (C. E.) Van Der Burg-Van De Plas, M. (M.) Heins, H. Lucas, E. (E.) Kortmann, B. Van Twillert, G. (G.) Renckens, R. (Rosemarijn) Ruiter-Pronk, D. (D.) Van Truijen-Oud, F.A. Cohen Stuart, J.W.T. (James) IJzerman, E.P.F. (Ed) Jansen, R.J. (Roel) Rozemeijer, W. (Wouter) Van Der Reijden, W.A. (W. A.) Berk, G.E.L. (Guido) van den Blok, W.L. (Willem) Frissen, P.H.J. Lettinga, K.D. (Kamilla) Schouten, W.E.M.I. (Ineke) Veenstra, J. (Jan) Brouwer, C.J. Geerders, G.F. Hoeksema, K. Kleene, M.J. Van Der Meché, I.B. Spelbrink, M. (M.) Toonen, A.J.M. Wijnands, S. (S.) Kwa, S.L.S. (Stefan) Regez, R.M. (Rosa) Crevel, R. (Reinout) van Keuter, M. (Monique) Ven, A.D. (Andre´) van Ter Hofstede, H.J.M. (H. J.M.) Dofferhoff, A.S.M. (Anton) Hoogerwerf, J. (J.) Grintjes-Huisman, K.J.T. De Haan, M. (M.) Marneef, M. (M.) Hairwassers, A. (A.) Rahamat-Langendoen, J. (J.) Stelma, F.F. (Foekje) Burger, D.M. (David) Gisolf, E.H. (Elisabeth) Hassing, R.J. (Robert) Claassen, M.A.A. (Mark) Ter Beest, G. (G.) Van Bentum, P.H.M. Langebeek, N. (Nienke) Tiemessen, R. (R.) Swanink, C. (Caroline) Lelyveld, S.F.L. van Soetekouw, R. (Robert) Van Der Prijt, L.M.M. Van Der Swaluw, J. (J.) Bermon, N. (N.) Jansen, R. (R.) Herpers, B.L. (B. L.) Veenendaal, D. (Dick) Verhagen, D.W.M. (Dominique) Van Wijk, M. (M.) Bierman, W.F.W. (Wouter) Bakker, M. (M.) Kleinnijenhuis, J. (J.) Kloeze, E. (E.) Stienstra, Y. (Y.) Wilting, K.R. Wouthuyzen-Bakker, M. (Marjan) Boonstra, P.A. (André) Van Der Meulen, P.A. De Weerd, D.A. Niesters, H.G.M. (Bert) Van Leer-Buter, C. (Coretta) Knoester, M. (M.) Hoepelman, I.M. (Ilja Mohandas) Barth, R.E. (R. E.) Bruns, A.H.W. (A. H.W.) Ellerbroek, P.M. (P.) Mudrikova, T. (Tania Tania) Oosterheert, J.J. (Jan Jelrik) Schadd, E.M. (E. M.) Wassenberg, M.W.M. Van Zoelen, M.A.D. (M. A.D.) Aarsman, K. (K.) Van Elst-Laurijssen, D.H.M. (D. H.M.) De Kroon, I. (I.) Van Rooijen, C.S.A.M. (C. S.A.M.) Van Berkel, M. (M.) Schuurman, R. (Rob) Verduyn-Lunel, F. Wensing, A. (Amj) Peters, E.J.G. Van Agtmael, M.A. (M. A.) Bomers, M. Heitmuller, M. (M.) Laan, L.M. Ang, C.W. (Wim) Houdt, R. van Pettersson, A. (Annika) Vandenbroucke-Grauls, C.M.J.E. (Christina) Bezemer, D.O. (Daniela) Sighem, A.I. (Ard) van Smit, C. (Cees) Wit, F. (Ferdinand) Boender, T.S. (T. S.) Zaheri, S. (S.) Hillebregt, M.M.J. (Mariska) De Jong, A. Bergsma, D. Grivell, S. Jansen, A. (A.) Raethke, M. Meijering, R. Rutkens, T. (T.) De Groot, L. (L.) Van Den Akker, M. (M.) Bakker, Y. Bezemer, M. (M.) Claessen, E. El Berkaoui, A. (A.) Geerlinks, J. (J.) Koops, J. (J.) Kruijne, E. Lodewijk, C. Van Der Meer, R. (R.) Munjishvili, L. Paling, F. (F.) Peeck, B. Ree, C. Regtop, R. Ruijs, Y. Schoorl, M. (Marianne) Timmerman, A. (A.) Tuijn, E. Veenenberg, L. Van Der Vliet, S. (S.) Wisse, A. (A.) De Witte, E.C. (E. C.) Woudstra, T. Tuk, B. (B.)
Dokumenttyp:	Artikel
Erscheinungsdatum:	2018
Schlagwörter:	Direct-acting antivirals / HIV/HCV coinfection / Treatment uptake
Sprache:	Englisch
Permalink:	https://search.fid-benelux.de/Record/base-29198564
Datenquelle:	BASE; Originalkatalog
Powered By:	BASE
Link(s) :	http://repub.eur.nl/pub/113204

Background The Netherlands has provided unrestricted access to direct-acting antivirals (DAAs) since November 2015. We analyzed the nationwide hepatitis C virus (HCV) treatment uptake among patients coinfected with human immunodeficiency virus (HIV) and HCV. Methods Data were obtained from the ATHENA HIV observational cohort in which >98% of HIV-infected patients ever registered since 1998 are included. Patients were included if they ever had 1 positive HCV RNA result, did not have spontaneous clearance, and were known to still be in care. Treatment uptake and outcome were assessed. When patients were treated more than once, data were included from only the most recent treatment episode. Data were updated until February 2017. In addition, each treatment center was queried in April 2017 for a data update on DAA treatment and achieved sustained virological response. Results Of 23574 HIV-infected patients ever linked to care, 1471 HCV-coinfected patients (69% men who have sex with men, 15% persons who [formerly] injected drugs, and 15% with another HIV transmission route) fulfilled the inclusion criteria. Of these, 87% (1284 of 1471) had ever initiated HCV treatment between 2000 and 2017, 76% (1124 of 1471) had their HCV infection cured; DAA treatment results were pending in 6% (92 of 1471). Among men who have sex with men, 83% (844 of 1022) had their HCV infection cured, and DAA treatment results were pending in 6% (66 of 1022). Overall, 187 patients had never initiated treatment, DAAs had failed in 14, and a pegylated interferon-alfa–based regimen had failed in 54. Conclusions Fifteen months after unrestricted DAA availability the majority of HIV/HCV-coinfected patients in the Netherlands have their HCV infection cured (76%) or are awaiting DAA treatment results (6%). This rapid treatment scale-up may contribute to future HCV elimination among these patients.