Concordance of Gleason grading with three-dimensional ultrasound systematic biopsy and biopsy core pre-embedding
Purpose: To determine the value of a three-dimensional (3D) greyscale transrectal ultrasound (TRUS)-guided prostate biopsy system and biopsy core pre-embedding method on concordance between Gleason scores of needle biopsies and radical prostatectomy (RP) specimens. Methods: Retrospective analysis of prostate biopsies and subsequent RP for PCa in the Jeroen Bosch Hospital, the Netherlands, from 2007 to 2016. Two cohorts were analysed: conventional 2D TRUS-guided biopsies and RP (2007–2013, n = 266) versus 3D TRUS-guided biopsies with pre-embedding (2013–2016, n = 129). The impact of 3D TRUS-gui... Mehr ...
| Verfasser: | |
|---|---|
| Dokumenttyp: | Artikel |
| Erscheinungsdatum: | 2018 |
| Reihe/Periodikum: | van der Aa , A A M A , Mannaerts , C K , van der Linden , H , Gayet , M , Schrier , B P , Mischi , M , Beerlage , H P & Wijkstra , H 2018 , ' Concordance of Gleason grading with three-dimensional ultrasound systematic biopsy and biopsy core pre-embedding ' , World Journal of Urology , vol. 36 , no. 6 , pp. 863-869 . https://doi.org/10.1007/s00345-018-2209-7 |
| Schlagwörter: | Biopsy / Neoplasm grading / Prostatectomy / Prostatic neoplasms / Three-dimensional imaging / Tissue embedding / Humans / Male / Netherlands / Prostate/pathology / Prostatic Neoplasms/pathology / Retrospective Studies / Endoscopic Ultrasound-Guided Fine Needle Aspiration |
| Sprache: | Englisch |
| Permalink: | https://search.fid-benelux.de/Record/base-29195530 |
| Datenquelle: | BASE; Originalkatalog |
| Powered By: | BASE |
| Link(s) : | https://research.tue.nl/en/publications/3395d26a-6ca9-4c47-8ced-fdf2c15f9812 |
Purpose: To determine the value of a three-dimensional (3D) greyscale transrectal ultrasound (TRUS)-guided prostate biopsy system and biopsy core pre-embedding method on concordance between Gleason scores of needle biopsies and radical prostatectomy (RP) specimens. Methods: Retrospective analysis of prostate biopsies and subsequent RP for PCa in the Jeroen Bosch Hospital, the Netherlands, from 2007 to 2016. Two cohorts were analysed: conventional 2D TRUS-guided biopsies and RP (2007–2013, n = 266) versus 3D TRUS-guided biopsies with pre-embedding (2013–2016, n = 129). The impact of 3D TRUS-guidance with pre-embedding on Gleason score (GS) concordance between biopsy and RP was evaluated using the κ-coefficient. Predictors of biopsy GS 6 upgrading were assessed using logistic regression models. Results: Gleason concordance was comparable between the two cohorts with a κ = 0.44 for the 3D cohort, compared to κ = 0.42 for the 2D cohort. 3D TRUS-guidance with pre-embedding, did not significantly affect the risk of biopsy GS 6 upgrading in univariate and multivariate analysis. Conclusions: 3D TRUS-guidance with biopsy core pre-embedding did not improve Gleason concordance. Improved detection techniques are needed for recognition of low-grade disease upgrading.