Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol.

TRIAL DESIGN: We present a study protocol for a multi-centre, randomised, double-blind, parallel-group, placebo-controlled trial that seeks to test the feasibility, acceptability and effectiveness of a 52-week period of treatment with the first-in-class co-stimulatory blocker abatacept for preventing or delaying the onset of inflammatory arthritis. METHODS: The study aimed to recruit 206 male or female subjects from the secondary care hospital setting across the UK and the Netherlands. Participants who were at least 18 years old, who reported inflammatory sounding joint pain (clinically suspic... Mehr ...

Verfasser: Al-Laith, Mariam
Jasenecova, Marianna
Abraham, Sonya
Bosworth, Aisla
Bruce, Ian N
Buckley, Christopher D
Ciurtin, Coziana
D'Agostino, Maria-Antonietta
Emery, Paul
Gaston, Hill
Isaacs, John D
Filer, Andrew
Fisher, Benjamin A
Huizinga, Thomas WJ
Ho, Pauline
Jacklin, Clare
Lempp, Heidi
McInnes, Iain B
Pratt, Arthur G
Östor, Andrew
Raza, Karim
Taylor, Peter C
van Schaardenburg, Dirkjan
Shivapatham, Dharshene
Wright, Alison J
Vasconcelos, Joana C
Kelly, Joanna
Murphy, Caroline
Prevost, A Toby
Cope, Andrew P
Dokumenttyp: Artikel
Erscheinungsdatum: 2020
Verlag/Hrsg.: Springer Science and Business Media LLC
Schlagwörter: Abatacept / Antibodies to citrullinated protein antigens / At risk / Autoantibodies / Double-blind / Intervention / Placebo-controlled / Pre-clinical phase / Randomised / Rheumatoid arthritis / Antirheumatic Agents / Arthritis / Rheumatoid / Biomarkers / Double-Blind Method / Drug Administration Schedule / Feasibility Studies / Female / Humans / Male / Multicenter Studies as Topic / Netherlands / Pregnancy / Randomized Controlled Trials as Topic / Time Factors / Treatment Outcome / United Kingdom
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29195173
Datenquelle: BASE; Originalkatalog
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Link(s) : https://www.repository.cam.ac.uk/handle/1810/307929