Background This study tests the buffering effects of positive youth development (PYD) factors against depression and suicidal ideation across Hong Kong and Dutch students. Methods We collected data on depression, suicidal ideation, history of childhood maltreatment, and PYD from 565 Dutch and Hong Kong undergraduates. The three PYD factors, prosocial attributes, positive identity, and cognitive-behavioral competence, were examined for their moderating role in the relationship among childhood maltreatment, depression, and suicidal ideation in path analysis. Results Direct protective effects are found for all PYD factors in both cultures, except for cognitive-behavioral competence in the Dutch sample. A buffering effect of the PYD factors is observed in the maltreatment-depression relationship in Dutch, but not in Hong Kong students. Only behavioral competence buffers against suicidal ideation in Dutch students, while other PYD factors show no buffering effect in both groups of participants. Conclusion The differences in relationships between two samples highlights the need to consider cultural differences.