INTRODUCTION: Molecular profiling of NSCLC is essential for optimising treatment decisions, but often incomplete. We assessed the efficacy of protocolised molecular profiling in the current standard-of-care (SoC) in a prospective observational study in the Netherlands and measured the effect of providing standardised diagnostic procedures. We also explored the potential of plasma-based molecular profiling in the primary diagnostic setting. METHODS: This multi-centre prospective study was designed to explore the performance of current clinical practice during the run-in phase using local SoC ti... Mehr ...
| Verfasser: |
Schouten, R D
Schouten, I
Schuurbiers, M M F
van der Noort, V
Damhuis, R A M
van der Heijden, E H F M
Burgers, J A
Barlo, N P
van Lindert, A S R
Maas, K W
van den Brand, J J G
Smit, A A J
van Haarst, J M W
van der Maat, B
Schuuring, E
Blaauwgeers, H
Willems, S M
Monkhorst, K
van den Broek, D
van den Heuvel, M M |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2024 |
| Reihe/Periodikum: |
Schouten , R D , Schouten , I , Schuurbiers , M M F , van der Noort , V , Damhuis , R A M , van der Heijden , E H F M , Burgers , J A , Barlo , N P , van Lindert , A S R , Maas , K W , van den Brand , J J G , Smit , A A J , van Haarst , J M W , van der Maat , B , Schuuring , E , Blaauwgeers , H , Willems , S M , Monkhorst , K , van den Broek , D & van den Heuvel , M M 2024 , ' Optimising primary molecular profiling in non-small cell lung cancer ' , PLoS ONE , vol. 19 , no. 7 , e0290939 . https://doi.org/10.1371/journal.pone.0290939 |
| Schlagwörter: |
Humans
/ Carcinoma
/ Non-Small-Cell Lung/genetics
/ Lung Neoplasms/genetics
/ Female
/ Male
/ Aged
/ Middle Aged
/ Prospective Studies
/ ErbB Receptors/genetics
/ Mutation
/ Anaplastic Lymphoma Kinase/genetics
/ Netherlands
/ Proto-Oncogene Proteins p21(ras)/genetics
/ Biomarkers
/ Tumor/genetics
/ Adult
/ 80 and over
/ B7-H1 Antigen/genetics
/ Gene Expression Profiling/methods |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29192605 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://hdl.handle.net/11370/df0d394e-d2ca-47b8-b3c8-f165c12ad801 |
