Risk of non-affective psychotic disorder or bipolar disorder in autism spectrum disorder:a longitudinal register-based study in the Netherlands

Background. Individuals with autism spectrum disorder (ASD) appear to be at increased risk of non-affective psychotic disorder (NAPD) and bipolar disorder (BD). However, most previous studies examined the co-occurrence of ASD and NAPD or BD, ignoring possible diagnostic bias and selection bias. We used longitudinal data from Dutch psychiatric case registers to assess the risk of NAPD or BD among individuals with ASD, and compared the results to those obtained for the Dutch population in earlier studies. Methods. Individuals with ASD (n = 17 234) were followed up between 16 and 35 years of age.... Mehr ...