The cost-effectiveness of surgical excision of colorectal endometriosis compared to ART treatment trajectory (TOSCA study) in the management of colorectal endometriosis and subfertility:Study protocol for a multicentre prospective patient preference trial in the Netherlands

Currently, the optimal treatment to increase the chance of pregnancy and live births in patients with colorectal endometriosis and subfertility is unknown. Evidence suggests that that both surgery and in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) are effective in improving the live birth rate (LBR) among these women. However, the available evidence is of low quality, reports highly heterogeneous results, lacks direct comparison between both treatment options, and does not assess whether a combination strategy results in a higher LBR compared to IVF/ICSI-only treatment... Mehr ...