An enhanced regimen as post-exposure chemoprophylaxis for leprosy:PEP+
The ongoing transmission of Mycobacterium (M.) leprae reflected in a very slow decline in leprosy incidence, forces us to be innovative and conduct cutting-edge research. Single dose rifampicin (SDR) as post-exposure prophylaxis (PEP) for contacts of leprosy patients, reduces their risk to develop leprosy by 60%. This is a promising new preventive measure that can be integrated into routine leprosy control programmes, as is being demonstrated in the Leprosy Post-Exposure Programme that is currently ongoing in eight countries.The limited (60%) effectiveness of SDR is likely due to the fact that... Mehr ...
Verfasser: |
Mieras, Liesbeth F
Taal, Anna T
van Brakel, Wim H
Cambau, Emmanuelle
Saunderson, Paul R
Smith, W Cairns S
Prakoeswa, Cita Rosita S
Astari, Linda
Scollard, David M
do Nascimento, Dejair Caitano
Grosset, Jacques
Kar, Hemanta K
Izumi, Shinzo
Gillini, Laura
Virmond, Marcos C L
Sturkenboom, Marieke G G |
Dokumenttyp: |
Artikel |
Erscheinungsdatum: |
2018 |
Reihe/Periodikum: |
Mieras , L F , Taal , A T , van Brakel , W H , Cambau , E , Saunderson , P R , Smith , W C S , Prakoeswa , C R S , Astari , L , Scollard , D M , do Nascimento , D C , Grosset , J , Kar , H K , Izumi , S , Gillini , L , Virmond , M C L & Sturkenboom , M G G 2018 , ' An enhanced regimen as post-exposure chemoprophylaxis for leprosy : PEP+ ' , BMC Infectious Diseases , vol. 18 , no. 1 , 506 . https://doi.org/10.1186/s12879-018-3402-4 |
Schlagwörter: |
Anti-Bacterial Agents/therapeutic use
/ Clarithromycin/therapeutic use
/ Fluoroquinolones/therapeutic use
/ Humans
/ Leprosy/drug therapy
/ Netherlands
/ Post-Exposure Prophylaxis/methods
/ Rifampin/therapeutic use |
Sprache: |
Englisch |
Permalink: |
https://search.fid-benelux.de/Record/base-29191864 |
Datenquelle: |
BASE;
Originalkatalog |
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BASE |
Link(s) :
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https://hdl.handle.net/11370/a431da5a-5b51-43c2-b166-c342872ef47b |