Depressive symptoms in subjects with diagnosed and undiagnosed type 2 diabetes

Objective: To investigate if disturbed glucose homeostasis or known diagnosis of diabetes was associated with depressive symptoms. The reason for the increased prevalence of depression in patients with Type 2 diabetes mellitus (DM2) is unknown. Methods: Within the Utrecht Health Project, an ongoing longitudinal study among inhabitants of a residential area of a large city in The Netherlands, 4747 subjects (age: 39.4 +/- 12.5 years) were classified into four mutually exclusive categories: normal fasting plasma glucose (FPG) (= 5.6 and = 7.0 mmol/l), and diagnosed DM2. Presence of depressive sym... Mehr ...

Verfasser: Knol, Mirjam J.
Heerdink, Eibert R.
Egberts, Antoine C. G.
Geerlings, Miriam I.
Gorter, Kees J.
Numans, Mattus E.
Grobbee, Diederick E.
Klungel, Olaf H.
Burger, Huibert
Dokumenttyp: Artikel
Erscheinungsdatum: 2007
Reihe/Periodikum: Knol , M J , Heerdink , E R , Egberts , A C G , Geerlings , M I , Gorter , K J , Numans , M E , Grobbee , D E , Klungel , O H & Burger , H 2007 , ' Depressive symptoms in subjects with diagnosed and undiagnosed type 2 diabetes ' , Psychosomatic Medicine , vol. 69 , no. 4 , pp. 300-305 . https://doi.org/10.1097/PSY.0b013e31805f48b9
Schlagwörter: depressive symptoms / diabetes / blood glucose / burden / INSULIN-RESISTANCE / MULTIPLE IMPUTATION / MELLITUS / HEALTH / ADULTS / PREVALENCE / RISK / METAANALYSIS / NETHERLANDS / PROJECTIONS
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29191325
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://hdl.handle.net/11370/6ab1326c-e25a-4239-aaff-340de5d1dc7a

Objective: To investigate if disturbed glucose homeostasis or known diagnosis of diabetes was associated with depressive symptoms. The reason for the increased prevalence of depression in patients with Type 2 diabetes mellitus (DM2) is unknown. Methods: Within the Utrecht Health Project, an ongoing longitudinal study among inhabitants of a residential area of a large city in The Netherlands, 4747 subjects (age: 39.4 +/- 12.5 years) were classified into four mutually exclusive categories: normal fasting plasma glucose (FPG) (= 5.6 and = 7.0 mmol/l), and diagnosed DM2. Presence of depressive symptoms was defined as a score of >= 25 on the depression subscale of the Symptom Check List (SCL-90) or self-reported use of antidepressants. Results: Diagnosed DM2 was associated with an increased risk of depressive symptoms (odds ratio (OR) = 1.69; 95% confidence interval (CI) 1.06-2.72) after adjustment for demographic and lifestyle variables. Additional adjustment for number of chronic diseases reduced the OR to 1.36 (95% CI 0.83-2.23). Impaired fasting glucose and undiagnosed DM2 were not associated with depressive symptoms. Conclusions: Our findings suggest that disturbed glucose homeostasis is not associated with depressive symptoms. The increased prevalence of depressive symptoms among patients with diagnosed DM2 suggests that depressive symptoms might be a consequence of the burden of diabetes. The number of chronic diseases seems to explain part of the association between DM2 and depressive symptoms.