Objectives: An established theory for the pathogenesis of tardive dyskinesia is disturbed dopaminergic receptor sensitivity and/or dopaminergic intracellular signaling. We examined associations between genetic variants of neurotransmitter receptors and tardive dyskinesia. Methods: We assessed tardive dyskinesia in Caucasian psychiatric inpatients from Siberia (N = 431) and a long-stay population from the Netherlands (N = 168). These patients were genotyped for 43 tag single nucleotide polymorphisms in five neurotransmitter receptor genes, and the results for the two populations were compared.... Mehr ...
| Verfasser: |
Ivanova, Svetlana A.
Loonen, Anton J .M.
Bakker, P. Roberto
Freidin, Maxim B.
ter Woerds, Nienke J.
Al Hadithy, Asmar F. Y.
Semke, Arkadiy V.
Fedorenko, Olga Yu
Brouwers, Jacobus R. B. J.
Bokhan, Nikolay A.
van Os, Jim
van Harten, Peter N.
Wilffert, Bob |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2016 |
| Reihe/Periodikum: |
Ivanova , S A , Loonen , A J M , Bakker , P R , Freidin , M B , ter Woerds , N J , Al Hadithy , A F Y , Semke , A V , Fedorenko , O Y , Brouwers , J R B J , Bokhan , N A , van Os , J , van Harten , P N & Wilffert , B 2016 , ' Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia : A comparison of genetic variants in two independent patient populations ' , SAGE Open Medicine , vol. 4 , pp. 1-9 . https://doi.org/10.1177/2050312116643673 |
| Schlagwörter: |
Dopaminergic receptor
/ Genetic variants
/ Glutamatergic receptor
/ Nmda receptor
/ Serotonergic receptor
/ Tardive dyskinesia mechanism
/ dopamine receptor
/ n methyl dextro aspartic acid receptor 2A
/ n methyl dextro aspartic acid receptor 2B
/ neurotransmitter receptor
/ serotonin receptor
/ Abnormal Involuntary Movement Scale
/ adult
/ article
/ cross-sectional study
/ DNA extraction
/ female
/ gene frequency
/ gene linkage disequilibrium
/ genetic model
/ genetic variability
/ human
/ major clinical study
/ male
/ Netherlands
/ orofacial dyskinesia
/ priority journal
/ Russian Federation
/ schizophrenia
/ schizotypal personality disorder
/ single nucleotide polymorphism
/ tardive dyskinesia |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29191193 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://hdl.handle.net/11370/5d1432df-674b-40ed-8f12-712ff292cab5 |
