Peatlands store vast amounts of carbon (C). However, land-use-driven drainage causes peat oxidation, resulting in CO 2 emission. There is a growing need for ground-truthing CO 2 emission and its potential drivers to better quantify long-term emission trends in peatlands. This will help improve National Inventory Reporting and ultimately aid the design and verification of mitigation measures. To investigate regional drivers of CO 2 emission, we estimated C budgets using custom-made automated chamber systems measuring CO 2 concentrations corrected for carbon export and import. Chamber systems were rotated among thirteen degraded peatland pastures in Friesland (the Netherlands). These peatlands varied in water table depth (WTD), drainage-irrigation management (fixed regulated ditch water level (DWL), subsurface irrigation, furrow irrigation, or dynamic regulated DWL), and soil moisture. We investigated (1) whether drainage-irrigation management and related hydrological drivers could explain variation in C budgets, (2) how nighttime ecosystem respiration (R eco night ) related to hydrological drivers, and (3) how C budgets compared with estimates from Tier 1 and Tier 2 models regularly used in National Inventory Reporting. Deep-drained peatlands largely overlapped with C budgets from shallow-drained peatlands. The variation in C budgets could not be explained with drainage-irrigation measures or annual WTD, likely because of high variation between sites. R eco night increased from 85 to 250 kg CO 2 ha −1 day −1 as the WTD dropped from 0 to 50 cm across all sites. A deeper WTD had no apparent effect on R eco night , which could be explained by the unimodal relationship we found between R eco night and soil moisture. Finally, C budgets estimated by Tier 1 emission factors and Tier 2 national models mismatched the between-site and between-year variation found in chamber-based estimated NECBs. To conclude, our study showed that shallow WTDs greatly determine C budgets and that regional C budgets, which can be accurately ...