Comprehensive Characterization of Escherichia coil O104:H4 Isolated from Patients in the Netherlands

In 2011, a Shiga toxin producing Enteroaggregative Escherichia coil (EAEC Stx2a+) 0104:H4 strain caused a serious outbreak of acute gastroenteritis and hemolyticuremic syndrome (HUS) in Germany. In 2013, E. col O104:H4 isolates were obtained from a patient with HUS and her friend showing only gastrointestinal complaints. The antimicrobial resistance and virulence profiles of these isolates together with three EAEC Stx2a+ O104:H4 isolates from 2011 were determined and compared. Whole-genome sequencing VGS) was performed for detailed characterization and to determine genetic relationship of the... Mehr ...