A 6-year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder

INTRODUCTION: Depressive disorder has been conceptualised as a condition of accelerated biological ageing. We operationalized a frailty index (FI) as marker for biological ageing aimed to explore the bidirectional, longitudinal association between frailty and either depressive symptoms or depressive disorder. METHODS: - A cohort study with 6-year follow-up including 377 older (≥60 years) outpatients with a DSM-IV defined depressive disorder and 132 never-depressed controls. Site visits at baseline, two and six-year follow-up were conducted and included the CIDI 2.0 to assess depressive disorde... Mehr ...