The Netherlands study of depression in older persons (NESDO): a prospective cohort study

BACKGROUND: To study late-life depression and its unfavourable course and co morbidities in The Netherlands. METHODS: We designed the Netherlands Study of Depression in Older Persons (NESDO), a multi-site naturalistic prospective cohort study which makes it possible to examine the determinants, the course and the consequences of depressive disorders in older persons over a period of six years, and to compare these with those of depression earlier in adulthood. RESULTS: From 2007 until 2010, the NESDO consortium has recruited 510 depressed and non depressed older persons (≥ 60 years) at 5 locat... Mehr ...

Verfasser: Comijs, Hannie C
van Marwijk, Harm W
van der Mast, Roos C
Naarding, Paul
Oude Voshaar, Richard C
Beekman, Aartjan Tf
Boshuisen, Marjolein
Dekker, Janny
Kok, Rob
de Waal, Margot Wm
Penninx, Brenda Wjh
Stek, Max L
Smit, Johannes H
Dokumenttyp: Artikel
Erscheinungsdatum: 2011
Reihe/Periodikum: Comijs , H C , van Marwijk , H W , van der Mast , R C , Naarding , P , Oude Voshaar , R C , Beekman , A T , Boshuisen , M , Dekker , J , Kok , R , de Waal , M W , Penninx , B W , Stek , M L & Smit , J H 2011 , ' The Netherlands study of depression in older persons (NESDO) : a prospective cohort study ' , BMC Research Notes , vol. 4 , 524 . https://doi.org/10.1186/1756-0500-4-524
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29190163
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://hdl.handle.net/11370/06274a94-b09e-4bf6-832f-3abe0bb8ea56

BACKGROUND: To study late-life depression and its unfavourable course and co morbidities in The Netherlands. METHODS: We designed the Netherlands Study of Depression in Older Persons (NESDO), a multi-site naturalistic prospective cohort study which makes it possible to examine the determinants, the course and the consequences of depressive disorders in older persons over a period of six years, and to compare these with those of depression earlier in adulthood. RESULTS: From 2007 until 2010, the NESDO consortium has recruited 510 depressed and non depressed older persons (≥ 60 years) at 5 locations throughout the Netherlands. Depressed persons were recruited from both mental health care institutes and general practices in order to include persons with late-life depression in various developmental and severity stages. Non-depressed persons were recruited from general practices. The baseline assessment included written questionnaires, interviews, a medical examination, cognitive tests and collection of blood and saliva samples. Information was gathered about mental health outcomes and demographic, psychosocial, biological, cognitive and genetic determinants. The baseline NESDO sample consists of 378 depressed (according to DSM-IV criteria) and 132 non-depressed persons aged 60 through 93 years. 95% had a major depression and 26.5% had dysthymia. Mean age of onset of the depressive disorder was around 49 year. For 33.1% of the depressed persons it was their first episode. 41.0% of the depressed persons had a co morbid anxiety disorder. Follow up assessments are currently going on with 6 monthly written questionnaires and face-to-face interviews after 2 and 6 years. CONCLUSIONS: The NESDO sample offers the opportunity to study the neurobiological, psychosocial and physical determinants of depression and its long-term course in older persons. Since largely similar measures were used as in the Netherlands Study of Depression and Anxiety (NESDA; age range 18-65 years), data can be pooled thus creating a large ...