Associations of adult-attained height and early life energy restriction with postmenopausal breast cancer risk according to estrogen and progesterone receptor status

Adult-attained height is a marker for underlying mechanisms, such as cell growth, that may also influence postmenopausal breast cancer (BC) risk, perhaps specifically hormone-sensitive BC subtypes. Early life energy restriction may inhibit these mechanisms, resulting in shorter height and a reduced postmenopausal BC risk. Women (62,573) from the Netherlands Cohort Study completed a self-administered questionnaire in 1986 when 55-69 years old, and were followed-up for 20.3 years (case-cohort: N-subcohort = 2,438; N-cases = 3,354). Cox multivariable-adjusted hazard ratios (HR) and 95% confidence... Mehr ...

Verfasser: Elands, Rachel J. J.
Offermans, Nadine S. M.
Simons, Colinda C. J. M.
Schouten, Leo J.
Verhage, Bas A.
van den Brandt, Piet A.
Weijenberg, Matty P.
Dokumenttyp: Artikel
Erscheinungsdatum: 2019
Reihe/Periodikum: Elands , R J J , Offermans , N S M , Simons , C C J M , Schouten , L J , Verhage , B A , van den Brandt , P A & Weijenberg , M P 2019 , ' Associations of adult-attained height and early life energy restriction with postmenopausal breast cancer risk according to estrogen and progesterone receptor status ' , International Journal of Cancer , vol. 144 , no. 8 , pp. 1844-1857 . https://doi.org/10.1002/ijc.31890
Schlagwörter: breast cancer epidemiology / adult-attained height / energy restriction / estrogen receptor status / progesterone receptor status / WORLD-WAR-II / PROSPECTIVE COHORT / GROWTH / CHILDHOOD / WEIGHT / FAMINE / NETHERLANDS / BIRTH / AGE / CONSEQUENCES
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29187770
Datenquelle: BASE; Originalkatalog
Powered By: BASE
Link(s) : https://cris.maastrichtuniversity.nl/en/publications/d755c3e1-9e46-4b32-8109-a4398ba57c8f

Adult-attained height is a marker for underlying mechanisms, such as cell growth, that may also influence postmenopausal breast cancer (BC) risk, perhaps specifically hormone-sensitive BC subtypes. Early life energy restriction may inhibit these mechanisms, resulting in shorter height and a reduced postmenopausal BC risk. Women (62,573) from the Netherlands Cohort Study completed a self-administered questionnaire in 1986 when 55-69 years old, and were followed-up for 20.3 years (case-cohort: N-subcohort = 2,438; N-cases = 3,354). Cox multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) were estimated for BC risk overall and by estrogen and progesterone receptor subtypes in relation to height and early life energy restriction during the Hunger Winter, War Years, and Economic Depression. Although energy restriction can only influence longitudinal growth in women exposed before and/or during the growth spurt, it may also influence BC risk when occurring after the growth spurt, possibly through different growth processes. Therefore, Cox analyses were additionally conducted according to timing of energy restriction in relation to the growth spurt. Height was associated with an increased BC risk (HRper 5cm = 1.07, 95%CI:1.01-1.13), particularly hormone receptor-positive BC. Energy restriction before and/or during the growth spurt was associated with a decreased hormone receptor-positive BC risk. Energy restriction during the Hunger Winter increased the estrogen receptor-negative BC risk regardless of the timing of energy restriction. In conclusion, height and energy restriction before and/or during the growth spurt were both associated with hormone receptor-positive BC risk, in the direction as expected, indicating critical exposure windows for hormonal growth-related mechanisms.