TRIDENT-2:National Implementation of Genome-wide Non-invasive Prenatal Testing as a First-Tier Screening Test in the Netherlands

The Netherlands launched a nationwide implementation study on non-invasive prenatal testing (NIPT) as a first-tier test offered to all pregnant women. This started on April 1, 2017 as the TRIDENT-2 study, licensed by the Dutch Ministry of Health. In the first year, NIPT was performed in 73,239 pregnancies (42% of all pregnancies), 7,239 (4%) chose first-trimester combined testing, and 54% did not participate. The number of trisomies 21 (239, 0.33%), 18 (49, 0.07%), and 13 (55, 0.08%) found in this study is comparable to earlier studies, but the Positive Predictive Values (PPV)-96% for trisomy... Mehr ...

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Verfasser: van der Meij, Karuna R. M.
Sistermans, Erik A.
Macville, Merryn V. E.
Stevens, Servi J. C.
Bax, Caroline J.
Bekker, Mireille N.
Bilardo, Caterina M.
Boon, Elles M. J.
Boter, Marjan
Diderich, Karin E. M.
de Die-Smulders, Christine E. M.
Duin, Leonie K.
Faas, Brigitte H. W.
Feenstra, Ilse
Haak, Monique C.
Hoffer, Mariette J. V.
den Hollander, Nicolette S.
Hollink, Iris H. I. M.
Jehee, Fernanda S.
Knapen, Maarten F. C. M.
Kooper, Angelique J. A.
van Langen, Irene M.
Lichtenbelt, Klaske D.
Linskens, Ingeborg H.
van Maarle, Merel C.
Oepkes, Dick
Pieters, Mijntje J.
Schuring-Blom, G. Heleen
Sikkel, Esther
Sikkema-Raddatz, Birgit
Smeets, Dominique F. C. M.
Srebniak, Malgorzata I.
Suijkerbuijk, Ron F.
Tan-Sindhunata, Gita M.
van der Ven, A. Jeanine E. M.
van Zelderen-Bhola, Shama L.
Henneman, Lidewij
Galjaard, Robert-Jan H.
Van Opstal, Diane
Weiss, Marjan M.
Dokumenttyp: Artikel
Erscheinungsdatum: 2019
Reihe/Periodikum: van der Meij , K R M , Sistermans , E A , Macville , M V E , Stevens , S J C , Bax , C J , Bekker , M N , Bilardo , C M , Boon , E M J , Boter , M , Diderich , K E M , de Die-Smulders , C E M , Duin , L K , Faas , B H W , Feenstra , I , Haak , M C , Hoffer , M J V , den Hollander , N S , Hollink , I H I M , Jehee , F S , Knapen , M F C M , Kooper , A J A , van Langen , I M , Lichtenbelt , K D , Linskens , I H , van Maarle , M C , Oepkes , D , Pieters , M J , Schuring-Blom , G H , Sikkel , E , Sikkema-Raddatz , B , Smeets , D F C M , Srebniak , M I , Suijkerbuijk , R F , Tan-Sindhunata , G M , van der Ven , A J E M , van Zelderen-Bhola , S L , Henneman , L , Galjaard , R-J H , Van Opstal , D , Weiss , M M & Dutch NIPT Consortium 2019 , ' TRIDENT-2 : National Implementation of Genome-wide Non-invasive Prenatal Testing as a First-Tier Screening Test in the Netherlands ' , American Journal of Human Genetics , vol. 105 , no. 6 , pp. 1091-1101 . https://doi.org/10.1016/j.ajhg.2019.10.005
Schlagwörter: CELL-FREE DNA / PREGNANT-WOMEN / DOWN-SYNDROME / HEALTH / ORGANIZATION / EXPERIENCE / IMPACT
Sprache: Englisch
Permalink: https://search.fid-benelux.de/Record/base-29187743
Datenquelle: BASE; Originalkatalog
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Link(s) : https://cris.maastrichtuniversity.nl/en/publications/d3526149-1e45-4dac-be25-7ed373b5ecc6