Outcome of BRCA1- compared with BRCA2-associated ovarian cancer: a nationwide study in the Netherlands
Recent studies suggested an improved overall survival (OS) for BRCA2- versus BRCA1-associated epithelial ovarian cancer (EOC), whereas the impact of chemotherapy is not yet clear. In a nationwide cohort, we examined the results of primary treatment, progression-free survival (PFS), treatment-free interval (TFI), and OS of BRCA1 versus BRCA2 EOC patients. Two hundred and forty-five BRCA1- and 99 BRCA2-associated EOC patients were identified through all Dutch university hospitals. Analyses were carried out with the Pearson's Chi-square test, Kaplan-Meier, and Cox regression methods. BRCA1 patien... Mehr ...
| Verfasser: |
Vencken, P. M. L. H.
Reitsma, W.
Kriege, M.
Mourits, M. J. E.
de Bock, G. H.
de Hullu, J. A.
van Altena, A. M.
Gaarenstroom, K. N.
Vasen, H. F. A.
Adank, M. A.
Schmidt, M. K.
van Beurden, M.
Zweemer, R. P.
Rijcken, F.
Slangen, B. F. M.
Burger, C. W.
Seynaeve, C. |
| Dokumenttyp: |
Artikel |
| Erscheinungsdatum: |
2013 |
| Reihe/Periodikum: |
Vencken , P M L H , Reitsma , W , Kriege , M , Mourits , M J E , de Bock , G H , de Hullu , J A , van Altena , A M , Gaarenstroom , K N , Vasen , H F A , Adank , M A , Schmidt , M K , van Beurden , M , Zweemer , R P , Rijcken , F , Slangen , B F M , Burger , C W & Seynaeve , C 2013 , ' Outcome of BRCA1- compared with BRCA2-associated ovarian cancer: a nationwide study in the Netherlands ' , Annals of Oncology , vol. 24 , no. 8 , pp. 2036-2042 . https://doi.org/10.1093/annonc/mdt068 |
| Schlagwörter: |
BRCA1
/ BRCA2
/ chemotherapy
/ ovarian cancer
/ response
/ survival |
| Sprache: |
Englisch |
| Permalink: |
https://search.fid-benelux.de/Record/base-29187357 |
| Datenquelle: |
BASE;
Originalkatalog |
| Powered By: |
BASE |
| Link(s) :
|
https://cris.maastrichtuniversity.nl/en/publications/a111313b-dbdf-4636-9c37-51953477e784 |
