Predicting clinical course in major depressive disorder:The association between DM-TRD score and symptom severity over time in 1115 outpatients

Background The Dutch Measure for Quantification of Treatment Resistance in Depression (DM-TRD) is a promising prediction tool for major depressive disorder (MDD) based on variables associated with treatment outcome. The objective of our study was to examine the association between the DM-TRD and clinical course in a large cohort of MDD outpatients receiving treatment as usual. Furthermore, we examined whether the addition of an item measuring the presence of childhood adversity improved this association. Methods We included 1115 subjects with MDD (according to the DSM-IV) who were naturalistic... Mehr ...